Evidence map›Paper›PMID 32994164›Full record

ArticleDevelopment (Cambridge, England)2020

RYK-mediated filopodial pathfinding facilitates midgut elongation.

Sha Wang, James P Roy, Abigail J Tomlinson, Ellen B Wang, Yu-Hwai Tsai, Lisa Cameron, Julie Underwood, Jason R Spence, Katherine D Walton, Steven A Stacker and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Human epiblast lumenogenesis: From a cell aggregate to a lumenal cyst.Seminars in cell & developmental biology · 2022
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sha WangDepartment of Dermatology and Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA sha.wang149@duke.edu dgumucio@umich.edu.ORCID 0000-0002-3945-2763
James P RoyTumour Angiogenesis and Microenvironment Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.
Abigail J TomlinsonDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ellen B WangDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yu-Hwai TsaiDepartment of Internal Medicine - Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Lisa CameronLight Microscopy Core Facility, Duke University, Durham, NC 27708, USA.
Julie UnderwoodDepartment of Dermatology and Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Jason R SpenceDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7869-3992
Katherine D WaltonDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Steven A StackerTumour Angiogenesis and Microenvironment Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.
Deborah L GumucioDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA sha.wang149@duke.edu dgumucio@umich.edu.ORCID 0000-0001-8883-383X
Terry LechlerDepartment of Dermatology and Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
University of Michigan · USDuke University · USThe Royal Melbourne Hospital · AUThe University of Melbourne · AU

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
Spindle Orientation in Skin Development and HomeostasisR01AR067203 · NIAMS · DUKE UNIVERSITY · PI LECHLER, TERRY H · 2015 to 2025
$3.9M
Role of Cell Adhesion and the Cytoskeleton in Epidermal IntegrityR01AR055926 · NIAMS · DUKE UNIVERSITY · PI LECHLER, TERRY H · 2009 to 2019
$3.7M
Morphogenesis of the fetal intestinal epitheliumR01DK089933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUMUCIO, DEBORAH L. · 2011 to 2019
$3.6M
Mechanisms of Hedgehog Regulation of Intestinal Villus MorphogenesisR01DK121166 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTON, KATHERINE DEMPSEY · 2019 to 2023
$1.8M
Intestinal Morphogenesis and DifferentiationR01DK117981 · NIDDK · DUKE UNIVERSITY · PI LECHLER, TERRY H · 2018 to 2021
$1.4M
Morphogenesis of the fetal intestinal epitheliumR56DK089933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUMUCIO, DEBORAH L. · 2010 to 2010
$380k
NIAMS NIH HHS R01 AR055926NIAMS NIH HHS R01 AR067203NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK089933NIDDK NIH HHS R01 DK117981NIDDK NIH HHS R01 DK121166NIDDK NIH HHS R56 DK089933
6 · The paper itself

Abstract

Between embryonic days 10.5 and 14.5, active proliferation drives rapid elongation of the murine midgut epithelial tube. Within this pseudostratified epithelium, nuclei synthesize DNA near the basal surface and move apically to divide. After mitosis, the majority of daughter cells extend a long, basally oriented filopodial protrusion, building a

Indexed as

AnimalsApoptosisCell NucleusDigestive SystemEpithelial CellsEpitheliumFemaleMaleMesodermMice, Inbred C57BLPseudopodiaReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase-like Orphan ReceptorsReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase-like Orphan ReceptorsRor2 protein, mouseRyk protein, mouseGut elongationInterkinetic nuclear migrationPseudostratifiedROR2RYKWNT5A

Identifiers

PMID32994164
PMCPMC7648600
OpenAlexW3090099460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.