ArticleCritical care (London, England)2020
Epinephrine's effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation.
Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Monitoring of Brain Tissue Oxygen Tension in Cardiac Arrest: a Translational Systematic Review from Experimental to Clinical Evidence.Neurocritical care · 2024Pooled it
- Comparison of the Hemodynamic Effects of Epinephrine on Blood Pressure Augmentation at 1-, 3-, and 5-Minute Dosing Intervals.Journal of the American Heart Association · 2026Article
- Evaluation of systemic and cerebral hemodynamics after systematic and early extracorporeal cardiopulmonary resuscitation in swine.Resuscitation plus · 2026Article
- Intramuscular epinephrine in cardiac arrest: A systematic review.Resuscitation plus · 2025Review
- The Latest in Resuscitation Research: Highlights From the 2024 American Heart Association's Resuscitation Science Symposium.Journal of the American Heart Association · 2025Article
- Delayed adrenaline administration prolongs adrenaline-to-ROSC interval in out-of-hospital cardiac arrest.British paramedic journal · 2025Article
- Predictors of response to peri-arrest bolus epinephrine in children.Resuscitation plus · 2025Article
- A novel translational bioinformatics framework for facilitating multimodal data analyses in preclinical models of neurological injury.Scientific reports · 2024Article
- Amplitude spectrum area is dependent on the electrocardiogram magnitude: evaluation of different normalization approaches.Physiological measurement · 2024Article
- Short-Term Neurologic Complications in Patients Undergoing Extracorporeal Membrane Oxygenation Support: A Review on Pathophysiology, Incidence, Risk Factors, and Outcomes.Pulmonary therapy · 2024Review
- The effects of bolus compared to continuous administration of adrenaline on cerebral oxygenation during experimental cardiopulmonary resuscitation.Resuscitation plus · 2024Article
- Hemodynamic Effect of Repeated Epinephrine Doses Decreases With Cardiopulmonary Resuscitation Cycle Progression.Journal of the American Heart Association · 2024Article
- Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements.PloS one · 2024Article
- Outcomes of Cardiopulmonary Resuscitation in the Pediatric Intensive Care of a Tertiary Center.Journal of pediatric intensive care · 2023Article
- Epinephrine-induced Effects on Cerebral Microcirculation and Oxygenation Dynamics Using Multimodal Monitoring and Functional Photoacoustic Microscopy.Anesthesiology · 2023Article
- A Narrative Review of Drug Therapy in Adult and Pediatric Cardiac Arrest.Reviews in cardiovascular medicine · 2023Review
- Differences in Cerebral Oxygenation in Cardiogenic and Respiratory Cardiac Arrest Before, During, and After Cardiopulmonary Resuscitation.Journal of clinical medicine · 2023Article
- The physiologic response to epinephrine and pediatric cardiopulmonary resuscitation outcomes.Critical care (London, England) · 2023Article
- Comment on: Post‑resuscitation diastolic blood pressure is a prognostic factor for outcomes of cardiac arrest patients.Journal of intensive care · 2022Article
- Hessian filter-assisted full diameter at half maximum (FDHM) segmentation and quantification method for optical-resolution photoacoustic microscopy.Biomedical optics express · 2022Article
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundDespite controversies, epinephrine remains a mainstay of cardiopulmonary resuscitation (CPR). Recent animal studies have suggested that epinephrine may decrease cerebral blood flow (CBF) and cerebral oxygenation, possibly potentiating neurological injury during CPR. We investigated the cerebrovascular effects of intravenous epinephrine in a swine model of pediatric in-hospital cardiac arrest. The primary objectives of this study were to determine if (1) epinephrine doses have a significant acute effect on CBF and cerebral tissue oxygenation during CPR and (2) if the effect of each subsequent dose of epinephrine differs significantly from that of the first.
methodsOne-month-old piglets (n = 20) underwent asphyxia for 7 min, ventricular fibrillation, and CPR for 10-20 min. Epinephrine (20 mcg/kg) was administered at 2, 6, 10, 14, and 18 min of CPR. Invasive (laser Doppler, brain tissue oxygen tension [PbtO
resultsWith the first epinephrine dose during CPR, CBF and cerebral tissue oxygenation increased by > 10%, as measured by each of the invasive and noninvasive measures (p < 0.001). The effects of epinephrine on CBF and cerebral tissue oxygenation decreased with subsequent doses. By the fifth dose of epinephrine, there were no demonstrable increases in CBF of cerebral tissue oxygenation. Invasive and noninvasive CBF measurements were highly correlated during asphyxia (slope effect 1.3, p < 0.001) and CPR (slope effect 0.20, p < 0.001).
conclusionsThis model suggests that epinephrine increases CBF and cerebral tissue oxygenation, but that effects wane following the third dose. Noninvasive measurements of neurological health parameters hold promise for developing and directing resuscitation strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.