SynthesisJournal of cardiothoracic surgery2020
Assessment of the risks of a myasthenic crisis after thymectomy in patients with myasthenia gravis: a systematic review and meta-analysis of 25 studies.
Synthesis in Journal of cardiothoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Myasthenia Gravis and Thymoma.Muscle & nerve · 2026Review
- Article
- Perioperative use of eculizumab in patients with thymoma-associated myasthenia gravis: A preliminary case series of five patients.IBRO neuroscience reports · 2026Article
- Clinical outcomes and follow-up after thymectomy in patients with myasthenia gravis: A Colombian cohort study.JTCVS open · 2026Article
- From Inoperable to Remission: Complete Response in Advanced Thymoma B3 With Immunotherapy-A Case Report.Respirology case reports · 2025Article
- Minimally invasive thymectomy for patients with thymoma: surgical, oncological and neurological outcomes.Indian journal of thoracic and cardiovascular surgery · 2025Article
- Efgartigimod for patients with thymoma associated generalized myasthenia gravis during the perioperative period: a four-case report.Frontiers in immunology · 2025Article
- Summary of the best evidence for the prevention and management of myasthenic crisis after thymectomy.Gland surgery · 2024Review
- Physiological and pathological roles of the thymus and value of thymectomy in myasthenia gravis: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
- Surgical management of thymic tumors: a narrative review with focus on robotic-assisted surgery.Mediastinum (Hong Kong, China) · 2024Review
- Nomogram for predicting the risk of postoperative myasthenic crisis in patients with thymectomy.Annals of clinical and translational neurology · 2023Article
- Analysis of influencing factors of postoperative myasthenic crisis in 564 patients with myasthenia gravis in a single center.Thoracic cancer · 2023Article
- Analysis of influencing factors of perioperative myasthenic crisis in 387 myasthenia gravis patients without thymoma in a single center.Journal of cardiothoracic surgery · 2023Article
- High indirect bilirubin levels as an independent predictor of postoperative myasthenic crisis: a single-center, retrospective study.Frontiers in neurology · 2023Article
- Childhood-Onset Myasthenia Gravis Patients Benefited from Thymectomy in a Long-Term Follow-up Observation.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2022Article
- Thymectomy in Myasthenia Gravis: A Narrative Review.Saudi journal of medicine & medical sciencesReview
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Authors and funding
5 authors.
Funding
Abstract
backgroundDespite the burgeoning literature describing preoperative and postoperative risks of a myasthenic crisis after thymectomy (MCAT) in patients with myasthenia gravis, substantial differences exist in the risk factors identified by previous studies. We conducted a meta-analysis to assess the reported risk factors and MCAT risk.
methodsWe collected relevant studies on the risk factors for MCAT by searching the PubMed, Embase, The Cochrane Library, China Biology Medicine (CBM), WanFang Data, VIP and CNKI databases. The search period ranged from the establishment of the database to November 2019.
resultsTwenty-five of the 458 identified studies were eligible for the meta-analysis. Seven retrospective cohort studies and 18 case-control studies were included, and 14 risk factors for MCAT were extracted. Meta-analyses of the association between MCAT and risk factors related to the patient's preoperative condition included a preoperative history of MC, preoperative bulbar symptoms, IIa + IIb + III + VI, IIb + III + VI, VI + V, dosage of pyridostigmine bromide prior to the operation, a preoperative AchR-Ab level > 100 (nm/L), preoperative pulmonary function, preoperative complications, and preoperative disease course. Meta-analyses of the association between MCAT and surgery-related risk factors included intraoperative blood loss > 1000 mL and the mode of operation. Meta-analyses of the association between MCAT and postoperative risk factors included postoperative lung infection, thymoma and the WHO classification. The operation time was not an independent risk factor for MCAT.
conclusionsThe independent risk factors for MCAT were a preoperative history of MC, preoperative bulbar symptoms, preoperative MG Osserman stage, preoperative dosage of pyridostigmine bromide, preoperative serum AchR-Ab level, lung function, major postoperative complications, disease duration before thymectomy, blood loss, thoracotomy, postoperative lung infection, thymoma, and WHO classification.
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