ArticleCardiovascular diabetology2020
Exposure-weighted scoring for metabolic syndrome and the risk of myocardial infarction and stroke: a nationwide population-based study.
Article in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 35 citations in OpenAlex.
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- Associations of Changes in Metabolic Syndrome Status and Risk Factor Count With Incident Cardiovascular Events Among Cancer Survivors.Journal of lipid and atherosclerosis · 2026Article
- Optimum Patient's Selection for Atrial Fibrillation Ablation Using Echocardiography.Diagnostics (Basel, Switzerland) · 2025Review
- Nutriomics and artificial intelligence nutrition obesity cohort (NAINOC): a design paper for a prospective cohort for nutrition and obesity research.Clinical hypertension · 2025Article
- Impact of postpartum weight change on metabolic syndrome and its components among women with recent gestational diabetes mellitus.Reproductive health · 2024Article
- Association between metabolic syndrome severity score and cardiovascular disease: results from a longitudinal cohort study on Chinese adults.Frontiers in endocrinology · 2024Article
- Influence of Phenotypes on the Metabolic Syndrome of Women with Polycystic Ovary Syndrome over a Six-Year Follow-Up in Brazil.Biomedicines · 2023Article
- Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study.BMC cardiovascular disorders · 2023Article
- PPAR Alpha Activation by Clofibrate Alleviates Ischemia/Reperfusion Injury in Metabolic Syndrome Rats by Decreasing Cardiac Inflammation and Remodeling and by Regulating the Atrial Natriuretic Peptide Compensatory Response.International journal of molecular sciences · 2023Article
- Circulating microRNAs Showed Specific Responses according to Metabolic Syndrome Components and Sex of Adults from a Population-Based Study.Metabolites · 2022Article
- Article
- Current Trends of Big Data Research Using the Korean National Health Information Database.Diabetes & metabolism journal · 2022Review
- Occult Blood in Feces Is Associated with Increased Risk of Psoriasis.Dermatology (Basel, Switzerland) · 2022Article
- Cumulative burden of metabolic syndrome and its components on the risk of atrial fibrillation: a nationwide population-based study.Cardiovascular diabetology · 2021Article
- Using Latent Class Analysis to Identify Different Risk Patterns for Patients With Masked Hypertension.Frontiers in cardiovascular medicine · 2021Article
- Evaluation of Anthropometric Indices and Lipid Parameters to Predict Metabolic Syndrome Among Adults in Mexico.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
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8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic syndrome (MetS) status changes over time, but few studies have investigated the relationship between the extent or duration of exposure to MetS and the risk of cardiovascular disease (CVD). We investigated the cumulative effects of MetS and its components on the risk of myocardial infarction (MI) and stroke.
methodsFrom the Korean National Health Insurance database, 2,644,851 people who received annual health examinations from 2010 to 2013 were recruited. Exposure-weighted scores for MetS during this 4-year period were calculated in two ways: cumulative number of MetS diagnoses (MetS exposure score, range: 0-4) and the composite of its five components (MetS component exposure score, range: 0-20). The multivariable Cox proportional-hazards model was used to assess CVD risk according to the exposure-weighted scores for MetS.
resultsMetS was identified at least once in 37.6% and persistent MetS in 8.2% of subjects. During the follow-up (median, 4.4 years), 10,522 cases of MI (0.4%) and 10,524 cases of stoke (0.4%) occurred. The risk of MI and stroke increased gradually with increasing exposure scores of MetS and its components (each P for trend < 0.0001). The hazard ratio [(HR) (95% CI)] of MI and stroke were 5.27 (4.20-6.62) and 3.90 (3.09-4.93), respectively, in those with a score of 20 compared with those with a MetS component exposure score of 0. People fulfilling only two MetS components out of 20 already had 22% increased risk of MI, and those with three MetS components had 24% increased risk of stroke. These associations were consistent in the subgroup and sensitivity analyses.
conclusionsA dose-response relationship between the cumulative exposure to metabolic disturbances and incident MI or stroke was evident. Even minimal exposure to MetS components was sufficient to increase the risk of CVD significantly, highlighting the importance of intensive risk management for the prevention of CVD.
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