Evidence map›Paper›PMID 32993612›Full record

ArticleBMC dermatology2020

A case of anti- pityriasis versicolor therapy that preserves healthy mycobiome.

Mariusz Dyląg, Ewa Leniak, Sebastian Gnat, Jacek C Szepietowski, Lukasz Kozubowski

Open access · diamondAbstract readCase Reports
In one paragraph

Article in BMC dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Tinea versicolor: an updated review.Drugs in context · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Mariusz DylągDepartment of Mycology and Genetics, Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland. mariusz.dylag@uwr.edu.pl.ORCID 0000-0003-2062-6169
Ewa LeniakMax Planck Institute of Molecular Plant Physiology, 14476, Potsdam, Germany.
Sebastian GnatDepartment of Veterinary Microbiology, Institute of Biological Bases of Animal Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.
Jacek C SzepietowskiDepartment and Clinic of Dermatology, Venereology and Allergology Wroclaw Medical University, Wroclaw, Poland.
Lukasz KozubowskiDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.
Clemson University · USMax Planck Institute of Molecular Plant Physiology · DEUniversity of Life Sciences in Lublin · PLUniversity of Wrocław · PLWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of Malassezia yeasts on skin mycobiome and health has received considerable attention recently. Pityriasis versicolor (PV), a common dermatosis caused by Malassezia genus worldwide, is a manifestation of dysbiosis. PV can be associated with hyper- and/or hypopigmented skin lesions. This disease entity is characterized by high percentage of relapses, which demands a proper antifungal therapy that is based on unambiguous species identification and drug susceptibility testing. CASE PRESENTATION: Comprehensive analysis of PV case in man presenting simultaneously hyper- and hypopigmented skin lesions was performed. Conventional and molecular diagnostic procedures revealed Malassezia furfur and Malassezia sympodialis, respectively as etiological agents of skin lesions observed. Susceptibility tests showed significantly lowered sensitivity of M. furfur cells to fluconazole. Based on susceptibility profiles local antifungal therapy with drugs characterized by entirely different mechanism of action was included.

conclusionsOur study indicates that cases of PV represented by two types of skin lesions in one patient may be associated with distinct Malassezia species. Moreover, as observed in this case, each of the isolated etiological agents of PV may differ significantly in susceptibility to antifungals. This can significantly complicate the treatment of dermatosis, which by definition is associated with a significant percentage of relapses. In the presented case localized topical treatment was sufficient and successful while allowing maintaining the physiological mycobiome.

Indexed as

Administration, TopicalAntifungal AgentsCiclopiroxDrug Therapy, CombinationHumansMalasseziaMaleMiddle AgedMycobiomePigmentation DisordersSkinTerbinafineTinea VersicolorAntifungal AgentsCiclopiroxTerbinafineDysbiosisHyperpigmentationHypopigmentationMalasseziaTreatment

Identifiers

PMID32993612
PMCPMC7526128
OpenAlexW3090491597

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.