ArticleBMC musculoskeletal disorders2020
Absence of pain in subjects with advanced radiographic knee osteoarthritis.
Article in BMC musculoskeletal disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Disease severity affects knee range of motion but not strength deficits in knee osteoarthritis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Application characteristics and clinical effectiveness of clinical finding staging in guiding non-surgical treatment of knee osteoarthritis involving 92 medical institutions.Journal of orthopaedic surgery and research · 2024Trial
- Biomechanical markers associations with pain, symptoms, and disability compared to radiographic severity in knee osteoarthritis patients: a secondary analysis from a cluster randomized controlled trial.BMC musculoskeletal disorders · 2022Trial
- Gender, age, disease severity, body mass index and diabetes may not affect response to subcutaneous tanezumab in patients with osteoarthritis after 16 weeks of treatment. A subgroup analysis of placebo-controlled trials.International journal of clinical practice · 2021Trial
- Beyond the algorithms: Challenges in predicting knee osteoarthritis pain from a machine learning point of view.Osteoarthritis imaging · 2026Article
- Localizing Knee Pain via Explainable Bayesian Generative Models and Counterfactual MRI: Data from the Osteoarthritis Initiative.Journal of imaging informatics in medicine · 2026Article
- Targeting synovial inflammation in knee osteoarthritis: translational insights for diagnosis and therapy.Journal of orthopaedic translation · 2026Review
- Article
- Rethinking the role of cartilage loss: the influence of intra- and extra-articular factors on symptoms in advanced knee osteoarthritis.Bone & joint open · 2025Article
- Integrative Phenotyping of Knee Osteoarthritis: Linking WOMAC Cut-Offs, Kellgren-Lawrence Grades, and Cluster Analysis for Personalized Care.Life (Basel, Switzerland) · 2025Article
- Relationship Between Incidence of Knee Pain and Ground Reaction Force During Stepping Motion in Older Adults.Geriatrics (Basel, Switzerland) · 2025Article
- The relation between radiographic knee osteoarthritis severity and pain is stronger among more frail people.Clinical rheumatology · 2025Article
- Emerging Therapy in Osteoarthritis: Mesenchymal Stem Cells, Secretomes, and Using Hydrogels to Enhance Efficacy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025Review
- The causal role of brain circuits in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- Factors influencing pain intensity in knee osteoarthritis: a cross-sectional biopsychosocial perspective.BMC musculoskeletal disorders · 2025Article
- Disparities in Clinical and Experimental Pain Between Non-Hispanic White and Asian American Individuals With Knee Osteoarthritis and the Role of Pain Catastrophizing: Pilot Study in Florida.Asian/Pacific Island nursing journal · 2025Article
- Article
- Ethnic differences in pain, function, and catastrophizing in South Florida adults with knee osteoarthritis.PloS one · 2025Article
- 9. Chronic knee pain.Pain practice : the official journal of World Institute of Pain · 2025Review
- Planned or recent first consultation with the general practitioner for knee complaints: Is it indicative of early-stage knee osteoarthritis?Osteoarthritis and cartilage open · 2024Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundTo investigate the frequency of pain among subjects with advanced radiographic knee osteoarthritis (OA) defined as Kellgren-Lawrence (KL) grade 4 and clinical features associated with pain.
methodsSubjects from the Hallym Aging Study (HAS), the Korean National Health and Nutrition Examination Survey (KNHANES), and the Osteoarthritis Initiative (OAI) were included. Participants were asked knee-specific questions regarding the presence of knee pain. Clinical characteristics associated with the presence of pain were evaluated with multivariable logistic regression analysis.
resultsThe study population consisted of 504, 10,152 and 4796 subjects from HAS, KNHANES, and OAI, respectively. KL grade 4 OA was identified in 9.3, 7.6, and 11.5% of subjects, while pain was absent in 23.5, 31.2, and 5.9% of subjects in KL grade 4 knee OA, respectively. After multivariable analysis, female gender showed a significant association with pain in the KNHANES group, while in the OAI group, younger age did. Advanced knee OA patients without pain did not differ from non-OA subjects in most items of SF-12 in both Korean and OAI subjects. Total WOMAC score was not significantly different between non-OA and advanced knee OA subjects without pain in the OAI.
conclusionsOur study showed that a considerable number of subjects with KL grade 4 OA did not report pain. In patients whose pain arises from causes other than structural damage of the joint, therapeutic decision based on knee X-ray would lead to suboptimal result. In addition, treatment options focusing solely on cartilage engineering, should be viewed with caution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.