ArticleBMC microbiology2020
Molecular epidemiology and risk factors of Stenotrophomonas maltophilia infections in a Chinese teaching hospital.
Article in BMC microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysis.Annals of clinical microbiology and antimicrobials · 2024Pooled it
- High abundance ofMicrobiology spectrum · 2026Article
- Risk factors and outcomes associated with difficult-to-treat resistance inEpidemiology and infection · 2026Article
- Therapeutic Potential of a NovelInternational journal of molecular sciences · 2026Article
- An Unexpected Inverse Relationship Between Biofilm Formation and Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2026Article
- Diversity Among Clinical and Fresh Produce Isolates ofFoods (Basel, Switzerland) · 2025Article
- Exploring the efficacy of combination of point-of-use filters and peracetic acid disinfection in reducing total viable counts in final rinse water of endoscopes.Scientific reports · 2025Article
- Cytotoxic Effect of Stenotrophomonas maltophilia Isolated from Prostate and Bladder Cancer Patients in Iraq.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Assessment of antimicrobial resistance, biofilm formation, and surface modification potential in hospital strains ofHeliyon · 2024Article
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- Ventilation Management in a Patient with Ventilation-Perfusion Mismatch in the Early Phase of Lung Injury and during the Recovery.Journal of clinical medicine · 2024Article
- Clonal spread of trimethoprim-sulfamethoxazole-resistant Stenotrophomonas maltophilia isolates in a tertiary hospital.GMS hygiene and infection control · 2024Article
- Antibiotic Resistance and Virulence Factors in Clinical Isolates ofInternational journal of microbiology · 2024Article
- Evaluation of ethanol and EDTA concentrations in the expression of biofilm-producing smf-1, rpfF genes in XDR clinical isolates of Stenotrophomonas maltophilia.BMC microbiology · 2023Article
- Impact of COVID-19 on the distribution of pathogenic bacteria in the lower respiratory tract of the elderly.Immunity, inflammation and disease · 2023Article
- Phenotypic Characteristics and Clonal Relationships ofInfection & chemotherapy · 2023Article
- Genotypic Diversity, Antibiotic Resistance, and Virulence Phenotypes ofAntibiotics (Basel, Switzerland) · 2023Article
- Comparative genomics analysis ofFrontiers in cellular and infection microbiology · 2023Article
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- Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStenotrophomonas maltophilia (S. maltophilia) is an important opportunistic pathogen that can be isolated in hospitals. With the abuse of broad spectrum antibiotics and invasive surgical devices, the rate of S. maltophilia infection is increasing every year. This study was an epidemiological analysis of the clinical and molecular characteristics of S. maltophilia infection in a Chinese teaching hospital. The goal was to obtain a comprehensive understanding of the status of S. maltophilia infection to provide strong epidemiological data for the prevention and treatment of S. maltophilia infection.
resultsA total of 93 isolates from Renji Hospital affiliated with the Shanghai Jiaotong University School of Medicine were included, in which 62 isolates were from male patients. In addition, 81 isolates were isolated from sputum samples. A total of 86 patients had underlying diseases. All patients received antibiotics. Multilocus sequence typing (MLST) analysis indicated that 61 different sequence types (STs) were found (including 45 novel STs), and MLST did not show significantly dominant STs. Pulsed field gel electrophoresis (PFGE) results showed that 93 isolates could be divided into 73 clusters, and they also showed weak genetic linkages between isolates. The resistant rates to trimethoprim/sulfamethoxazole (TMP/SMX) and levofloxacin were 9.7 and 4.3%, respectively, and all isolates were susceptible to minocycline. Four virulence gene's loci Stmpr1, Stmpr2, Smf-1, and Smlt3773 were positive in 79.6, 91.4, 94.6, and 52.7% of the isolates, respectively. Three biofilm genes rmlA, spgM, and rpfF were positive in 82.8, 92.5, and 64.5% of the isolates, respectively. Mean biofilm forming level of OD
conclusionsMost of the patients had prior medical usage histories and baseline diseases. The positive rate of virulence genes was high, the drug resistance rate of S. maltophilia was low, and the biofilm formation ability was strong. The increased use of antibiotics was an independent risk factor for S. maltophilia infection, which should receive more attention. No obvious clonal transmissions were found in the same departments.
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