Observational studyJournal of the American Heart Association2020
Association of Isolated Diastolic Hypertension Based on the Cutoff Value in the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines With Subsequent Cardiovascular Events in the General Population.
Observational study in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- A cohort study and meta-analysis of isolated diastolic hypertension: searching for a threshold to guide treatment.European heart journal · 2021Pooled it
- Cardiovascular Risk in Patients With Treated Isolated Diastolic Hypertension and Isolated Low Diastolic Blood Pressure.Journal of the American Heart Association · 2024Trial
- Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Low-Density-Lipoprotein Cholesterol Control and Treatment Status 1 Year after the Initial Health Checkup in Individuals with Referral-Level LDL Cholesterol.Journal of atherosclerosis and thrombosis · 2026Article
- Association of changes in body weight and waist circumference with a subsequent risk of developing hypertension in men requiring specific healthcare guidance.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- App-Recorded Daily Step Counts, Sex Differences, and Risk of Cardiovascular Outcomes Among Middle-Aged Population.Journal of the American Heart Association · 2025Article
- Prevalence of prediabetes and associated risk factors among peri-urban dwelling adults in Blantyre, Malawi.Malawi medical journal : the journal of Medical Association of Malawi · 2025Article
- Association between cardiovascular risk and diastolic blood pressure in older adults with systolic blood pressure less than 130mmHg: a prospective cohort study from 2014 to 2022.Aging clinical and experimental research · 2024Article
- Usefulness and caveats of real-world data for research on hypertension and its association with cardiovascular or renal disease in Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Sex Differences in the Association Between Depression and Incident Cardiovascular Disease.JACC. Asia · 2024Article
- Sex Differences in the Relationship Between Schizophrenia and the Development of Cardiovascular Disease.Journal of the American Heart Association · 2024Article
- Cumulative Diastolic Blood Pressure Burden in Normal Systolic Blood Pressure and Cardiovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Association of Metabolic Dysfunction-Associated Fatty Liver Disease With Risk of HF and AF.JACC. Asia · 2023Article
- Isolated Diastolic Hypertension and Kidney and Cardiovascular Outcomes in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.Kidney medicine · 2023Article
- Assessment of Blood Pressure in Irradiated Rhesus Macaques (Macaca mulatta).Radiation research · 2023Article
- Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation.Journal of the American Heart Association · 2023Article
- Age-Dependent Association Between Modifiable Risk Factors and Incident Cardiovascular Disease.Journal of the American Heart Association · 2023Article
- Interaction of Blood Pressure and Glycemic Status in Developing Cardiovascular Disease: Analysis of a Nationwide Real-World Database.Journal of the American Heart Association · 2023Observational
- Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study).Journal of the American Heart Association · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines lowered the threshold of blood pressure (BP) for hypertension to 130/80 mm Hg. However, the clinical significance of isolated diastolic hypertension (IDH) according to the cutoff value of the 2017 ACC/AHA guidelines was uncertain. Methods and Results We analyzed the claims database of Japan Medical Data Center (a nationwide epidemiological database). We excluded individuals who were aged <20 years, had systolic hypertension, were taking antihypertensive medication, or had prevalent cardiovascular disease, and studied 1 746 493 individuals (mean age, 42.9±10.7 years; 961 097 men [55.0%]). The average observational period was 1107±855 days. Stage 1 IDH, defined as diastolic BP 80 to 89 mm Hg, and stage 2 IDH, defined as diastolic BP ≥90 mm Hg, were found in 230 513 (13.2%) and 16 159 (0.9%) individuals, respectively. Compared with individuals with normal diastolic BP, individuals with stage 1 and stage 2 IDH were older and more likely to be men. Prevalence of classic risk factors was higher in patients with IDH. Kaplan-Meier curves showed that stage 1 and stage 2 IDH were associated with a higher incidence of cardiovascular events, defined as myocardial infarction, angina pectoris, and stroke. Multivariable analysis showed that stage 1 (hazard ratio [HR], 1.17) and stage 2 (HR, 1.28) IDH were independently associated with a higher incidence of cardiovascular events. Subgroup analyses showed that the association of IDH with cardiovascular events was seen irrespective of age and sex. Conclusions The analysis of a nationwide epidemiological database showed that IDH based on the cutoff value in the 2017 ACC/AHA BP guidelines was associated with an elevated risk of subsequent cardiovascular events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.