ArticleMetabolites2020
Identification and Reproducibility of Plasma Metabolomic Biomarkers of Habitual Food Intake in a US Diet Validation Study.
Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate.Environment international · 2023Pooled it
- Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial.Nature communications · 2026Trial
- Plasma Metabolites Associated with a Protein-Rich Dietary Pattern: Results from the OmniHeart Trial.Molecular nutrition & food research · 2022Trial
- Associations of coffee, alcohol, medication and supplement use with the metabolome and lipidome: an observational study of premenopausal women.Metabolomics : Official journal of the Metabolomic Society · 2026Observational
- Metabolomic Signatures of Dietary Patterns and Incident Radiographic Knee Osteoarthritis: A Case-Cohort Study From the Osteoarthritis Initiative.The Journal of rheumatology · 2026Article
- Anthocyanins and Metabolic Disease: A New Frontier in Precision Nutrition.Antioxidants (Basel, Switzerland) · 2026Review
- Elucidating the causal effects of plasma metabolites on breast cancer from multiple perspectives.International journal of surgery (London, England) · 2026Article
- Metabolic variation reflects dietary exposure in a multi-ethnic Asian population.Nature metabolism · 2025Article
- Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2).Clinical pharmacology and therapeutics · 2025Article
- Association of Ultraprocessed Foods Intake with Untargeted Metabolomics Profiles in Adolescents and Young Adults in the DONALD Cohort Study.The Journal of nutrition · 2024Article
- Dietary biomarkers-an update on their validity and applicability in epidemiological studies.Nutrition reviews · 2024Review
- Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake.The American journal of clinical nutrition · 2024Article
- OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease in the Swedish Mammography Cohort.Environmental science & technology · 2024Article
- Exploring Human Metabolome after Wine Intake-A Review.Molecules (Basel, Switzerland) · 2023Review
- Identification of Single and Combined Serum Metabolites Associated with Food Intake.Metabolites · 2022Article
- Serum metabolomic signatures of plant-based diets and incident chronic kidney disease.The American journal of clinical nutrition · 2022Article
- Plasma metabolomic profiling of hypertrophic cardiomyopathy patients before and after surgical myectomy suggests postoperative improvement in metabolic function.BMC cardiovascular disorders · 2021Article
- Dietary Management of Heart Failure: DASH Diet and Precision Nutrition Perspectives.Nutrients · 2021Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous metabolomic studies have identified putative blood biomarkers of dietary intake. These biomarkers need to be replicated in other populations and tested for reproducibility over time for the potential use in future epidemiological studies. We conducted a metabolomics analysis among 671 racially/ethnically diverse men and women included in a diet validation study to examine the correlation between >100 food groups/items (101 by a food frequency questionnaire (FFQ), 105 by 24-h diet recalls (24HRs)) with 1141 metabolites measured in fasting plasma sample replicates, six months apart. Diet-metabolite associations were examined by Pearson's partial correlation analysis. Biomarker reproducibility was assessed using intraclass correlation coefficients (ICCs). A total of 677 diet-metabolite associations were identified after Bonferroni adjustment for multiple comparisons and restricting absolute correlation coefficients to greater than 0.2 (601 associations using the FFQ and 395 using 24HRs). The median ICCs of the 238 putative biomarkers was 0.56 (interquartile range 0.46-0.68). In this study, with repeated FFQs, 24HRs and plasma metabolic profiles, we identified several potentially novel food biomarkers and replicated others found in our previous study. Our findings contribute to the growing literature on food-based biomarkers and provide important information on biomarker reproducibility which could facilitate their utilization in future nutritional epidemiological studies.
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