Evidence map›Paper›PMID 32993064›Full record

ArticleFoods (Basel, Switzerland)2020

Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control.

Oscar R Estupiñan, Pablo Garcia-Manrique, Maria Del Carmen Blanco-Lopez, Maria Matos, Gemma Gutiérrez

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Oscar R EstupiñanInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33006 Oviedo, Spain.
Pablo Garcia-ManriqueDepartment of Physical and Analytical Chemistry, University of Oviedo, 33006 Oviedo, Spain.ORCID 0000-0003-2489-5753
Maria Del Carmen Blanco-LopezDepartment of Physical and Analytical Chemistry, University of Oviedo, 33006 Oviedo, Spain.ORCID 0000-0002-9776-9013
Maria MatosDepartment of Chemical Engineering and Environmental Technology, University of Oviedo, 33006 Oviedo, Spain.ORCID 0000-0002-6980-0554
Gemma GutiérrezDepartment of Chemical Engineering and Environmental Technology, University of Oviedo, 33006 Oviedo, Spain.ORCID 0000-0003-2700-4944

Funding

Europaen Commision 813439 - BREAK BIOFILMSMinisterio de Economía y Competitividad MAT2017-84959-C2-1-RPrincipado de asturias IDI/2018/000185
6 · The paper itself

Abstract

Vesicular nanocarriers have an important role in drug delivery and dietary supplements. Size control and optimization of encapsulation efficiency (EE) should be optimized for those applications. In this work, we report on the identification of the crucial step (injection, evaporation, or sonication) innanovesicles (transfersomes and niosomes) preparation by theethanol injection method (EI). The identification of each production step on the final vesicle size was analyzed in order to optimize further scale-up process. Results indicated that the final size of transfersomeswas clearly influenced by the sonication step while the final size of niosomes was mainly governed by the injection step. Measurements of final surface tension of the different vesicular systems prepared indicate a linear positive tendency with the vesicle size formed. This relation could help to better understand the process and design a vesicular size prediction model for EI. Vitamin D3 (VitD3) was encapsulated in the systems formulated with encapsulation efficiencies larger than 90%. Interaction between the encapsulated compound and the membrane layer components is crucial for vesicle stability. This work has an impact on the scaling-up production of vesicles for further food science applications.

Indexed as

encapsulation efficiencyethanol injection methodniosomessurface tensiontransfersomesvesicles stability

Identifiers

PMID32993064
PMCPMC7600288

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.