Evidence map›Paper›PMID 32992967›Full record

ArticleCells2020

Tick-Borne Encephalitis: A Differential Pattern of Intrathecal Humoral Immune Response and Inflammatory Cell Composition Compared with Other Viral CNS Infections.

Makbule Senel, Daniel Rapp, Benjamin Mayer, Sarah Jesse, Sigurd D Süssmuth, Markus Otto, Jan Lewerenz, Hayrettin Tumani

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. New Aspects on Tick-borne Encephalitis in Children.The Pediatric infectious disease journal · 2026
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Makbule SenelDepartment of Neurology, University of Ulm, 89081 Ulm, Germany.ORCID 0000-0002-2737-7495
Daniel RappDepartment of Neurology, University of Ulm, 89081 Ulm, Germany.
Benjamin MayerInstitute of Epidemiology and Medical Biometry, Ulm University, 89075 Ulm, Germany.
Sarah JesseDepartment of Neurology, University of Ulm, 89081 Ulm, Germany.
Sigurd D SüssmuthDepartment of Neurology, University of Ulm, 89081 Ulm, Germany.
Markus OttoDepartment of Neurology, University of Ulm, 89081 Ulm, Germany.ORCID 0000-0003-4273-4267
Jan LewerenzDepartment of Neurology, University of Ulm, 89081 Ulm, Germany.
Hayrettin TumaniDepartment of Neurology, University of Ulm, 89081 Ulm, Germany.
Universität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate whether and how cerebrospinal fluid (CSF) findings can contribute to distinguish tick-borne encephalitis (TBE) from herpes simplex virus (HSV) and varicella zoster virus (VZV) induced central nervous system (CNS) infections (HSV-I, VZV-I). Chart review and identification of TBE, HSV- I, and VZV-I was carried out, fulfilling the following criteria: (1) clinical signs of encephalitis and/or meningitis, (2) complete CSF analysis and confirmed viral etiology by either PCR or antibody testing in CSF, (3) hospitalized patients, and (4) available brain magnetic resonance imaging (MRI). Fifty-nine patients with 118 CSF/serum pairs were included. These comprised 21 with TBE (35 CSF/serum pairs), 20 (40 CSF/serum pairs) with HSV-I, and 18 (43 CSF/serum pairs) with VZV-I. In contrast to HSV-I and VZV-I, CSF cell differentiation in TBE showed more often an increased (>20%) proportion of granulocytes (

Indexed as

Diagnosis, DifferentialAdultAgedCentral Nervous System InfectionsEncephalitis, Tick-BorneFemaleHerpesvirus 3, HumanHumansImmunity, HumoralImmunoglobulin MLeukocytosisMagnetic Resonance ImagingMaleMeningitisMiddle AgedSimplexvirusImmunoglobulin MencephalitisHSVmeningitisTBETBEVtick-borne encephalitisviralVZV

Identifiers

PMID32992967
PMCPMC7599799
OpenAlexW3088763660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.