Evidence map›Paper›PMID 32992946›Full record

ArticleViruses2020

Atypical Porcine Pestivirus Circulation and Molecular Evolution within an Affected Swine Herd.

Alba Folgueiras-González, Robin van den Braak, Bartjan Simmelink, Martin Deijs, Lia van der Hoek, Ad de Groof

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alba Folgueiras-GonzálezDepartment Discovery & Technology, MSD Animal Health, Wim de Körverstraat 35, P.O. Box 31, 5830AA Boxmeer, The Netherlands.ORCID 0000-0002-7688-6288
Robin van den BraakDepartment Discovery & Technology, MSD Animal Health, Wim de Körverstraat 35, P.O. Box 31, 5830AA Boxmeer, The Netherlands.ORCID 0000-0002-7492-0614
Bartjan SimmelinkDepartment Discovery & Technology, MSD Animal Health, Wim de Körverstraat 35, P.O. Box 31, 5830AA Boxmeer, The Netherlands.
Martin DeijsLaboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam UMC Location AMC, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.
Lia van der HoekLaboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam UMC Location AMC, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.ORCID 0000-0003-2803-642X
Ad de GroofDepartment Discovery & Technology, MSD Animal Health, Wim de Körverstraat 35, P.O. Box 31, 5830AA Boxmeer, The Netherlands.ORCID 0000-0002-4129-4354
Amsterdam University Medical Centers · NLMSD (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical porcine pestivirus (APPV) is a single-stranded RNA virus from the family Flaviviridae, which is linked to congenital tremor (CT) type A-II in newborn piglets. Here, we retrospectively investigated the molecular evolution of APPV on an affected herd between 2013 and 2019. Monitoring was done at regular intervals, and the same genotype of APPV was found during the entire study period, suggesting no introductions from outside the farm. The nucleotide substitutions over time did not show substantial amino acid variation in the structural glycoproteins. Furthermore, the evolution of the virus showed mainly purifying selection, and no positive selection. The limited pressure on the virus to change at immune-dominant regions suggested that the immune pressure at the farm might be low. In conclusion, farms can have circulation of APPV for years, and massive testing and removal of infected animals are not sufficient to clear the virus from affected farms.

Indexed as

Evolution, MolecularAnimalsAnimals, NewbornDisease OutbreaksGenetic VariationGenome, ViralPestivirusPestivirus InfectionsPhylogenyRetrospective StudiesSelection, GeneticSwineSwine DiseasesTremorViral ProteinsViral Proteinsasymptomaticatypical porcine pestivirus (APPV)congenital tremorgenomic sequencepestivirusphylogenetic analysispurifying selectionswineviral persistence

Identifiers

PMID32992946
PMCPMC7599615
OpenAlexW3089015391

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.