ReviewDiagnostics (Basel, Switzerland)2020
Myocardial Function, Heart Failure and Arrhythmia in Marfan Syndrome: A Systematic Literature Review.
Review in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Skeletal muscle alterations in Marfan syndrome: a systematic review.Journal of muscle research and cell motility · 2025Pooled it
- Article
- Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.Research square · 2026Article
- Systematic Disruption of Zebrafish Fibrillin Genes Identifies a Translational Zebrafish Model for Marfan Syndrome.JACC. Basic to translational science · 2026Article
- Association between Mitral Valve Pathology and Ventricular Ectopy in the Pediatric Marfan Population.Pediatric cardiology · 2026Article
- Is cardiomyopathy intrinsic to Marfan syndrome?Pediatric research · 2025Article
- Ventricular dispersion and repolarization in Marfan syndrome: A clinical analysis.Heart rhythm O2 · 2025Article
- Diastolic Function and Left Atrial Mechanics in Children With Marfan and Loeys-Dietz Syndrome.CJC pediatric and congenital heart disease · 2025Article
- Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band.The Journal of general physiology · 2025Article
- Unraveling a novel FBN1 variant in Marfan syndrome with dilated aortic root manifestation.BMC medical genomics · 2025Article
- Advances in Cardiovascular Multimodality Imaging in Patients with Marfan Syndrome.Diagnostics (Basel, Switzerland) · 2025Review
- Interpretation and classification of FBN1 variants associated with Marfan syndrome: consensus recommendations from the Clinical Genome Resource's FBN1 variant curation expert panel.Genome medicine · 2024Article
- Assessment of Myocardial Fibrosis in Marfan Syndrome Using Cardiac Magnetic Resonance Imaging.Molecular genetics & genomic medicine · 2024Article
- Marfan Syndrome, Hypertrophic Cardiomyopathy And Long QT A Rare Association Causing Sudden Death.Arquivos brasileiros de cardiologia · 2024Article
- Pediatric Chest Pain: A Review of Diagnostic Tools in the Pediatric Emergency Department.Diagnostics (Basel, Switzerland) · 2024Review
- Human stem cell models for Marfan syndrome: aFrontiers in cell and developmental biology · 2024Review
- Is Marfan Syndrome Associated with Primary Structural Changes in the Left Atrium?Diagnostics (Basel, Switzerland) · 2023Article
- Hyperuricaemia Does Not Interfere with Aortopathy in a Murine Model of Marfan Syndrome.International journal of molecular sciences · 2023Article
- Transseptal approach for catheter ablation of left-sided accessory pathways in children with Marfan syndrome: A case report.World journal of clinical cases · 2023Article
- Sleep apnea predicts cardiovascular death in patients with Marfan syndrome: a cohort study.The EPMA journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marfan syndrome (MFS) is a heritable systemic connective tissue disease with important cardiovascular involvement, including aortic root dilatation and mitral valve prolapse. Life expectancy in patients with MFS is mainly determined by cardiovascular complications, among which aortic dissection or rupture are most dreaded. In recent years, heart failure and ventricular arrhythmia have drawn attention as extra-aortic cardiovascular manifestations and as additional reported causes of death. Imaging studies have provided data supporting a primary myocardial impairment in the absence of valvular disease or cardiovascular surgery, while studies using ambulatory ECG have demonstrated an increased susceptibility to ventricular arrhythmia. In this paper, current literature was reviewed in order to provide insights in characteristics, pathophysiology and evolution of myocardial function, heart failure and ventricular arrhythmia in MFS.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.