Evidence map›Paper›PMID 32992799›Full record

ArticleBiosensors2020

Nanofluidic Immobilization and Growth Detection of

Jan F Busche, Svenja Möller, Ann-Kathrin Klein, Matthias Stehr, Foelke Purr, Margherita Bassu, Thomas P Burg, Andreas Dietzel

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jan F BuscheInstitute of Microtechnology, Technische Universität Braunschweig, 38124 Braunschweig, Germany.ORCID 0000-0001-5023-5439
Svenja MöllerInstitute of Microtechnology, Technische Universität Braunschweig, 38124 Braunschweig, Germany.ORCID 0000-0002-6607-426X
Ann-Kathrin KleinInstitute of Microtechnology, Technische Universität Braunschweig, 38124 Braunschweig, Germany.
Matthias StehrLionex Diagnostics & Therapeutics GmbH, 38124 Braunschweig, Germany.
Foelke PurrInstitute of Microtechnology, Technische Universität Braunschweig, 38124 Braunschweig, Germany.
Margherita BassuMax Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Thomas P BurgMax Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Andreas DietzelInstitute of Microtechnology, Technische Universität Braunschweig, 38124 Braunschweig, Germany.
Technische Universität Braunschweig · DEMax Planck Institute for Biophysical Chemistry · DELionex (Germany) · DETechnische Universität Darmstadt · DE

Funding

Bundesministerium für Bildung und Forschung 13N13834Bundesministerium für Bildung und Forschung 13N13836Bundesministerium für Bildung und Forschung 13N13837Bundesministerium für Bildung und Forschung 13N13838
6 · The paper itself

Abstract

Infections with antimicrobial resistant bacteria are a rising threat for global healthcare as more and more antibiotics lose their effectiveness against bacterial pathogens. To guarantee the long-term effectiveness of broad-spectrum antibiotics, they may only be prescribed when inevitably required. In order to make a reliable assessment of which antibiotics are effective, rapid point-of-care tests are needed. This can be achieved with fast phenotypic microfluidic tests, which can cope with low bacterial concentrations and work label-free. Here, we present a novel optofluidic chip with a cross-flow immobilization principle using a regular array of nanogaps to concentrate bacteria and detect their growth label-free under the influence of antibiotics. The interferometric measuring principle enabled the detection of the growth of

Indexed as

Lab-On-A-Chip DevicesMicrofluidicsPoint-of-Care TestingAnti-Bacterial AgentsBacteriaEscherichia coliHumansMicrobial Sensitivity TestsAnti-Bacterial Agentsantibiotic resistance testmicrofabricationnanofluidicnano-gratingoptofluidic

Identifiers

PMID32992799
PMCPMC7650788
OpenAlexW3087913336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.