Trial reportNutrients2020
The Effects of 6-Month Vitamin D Supplementation during the Non-Surgical Treatment of Periodontitis in Vitamin-D-Deficient Patients: A Randomized Double-Blind Placebo-Controlled Study.
Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03162406 (Effects of Vitamin D Supplementation During a Non-surgical Treatment of Generalized Chronic Periodontitis), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Vitamin D Supplementation During a Non-surgical Treatment of Generalized Chronic Periodontitis: A Randomized Double-blinded Placebo Controlled Clinical Trial
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Vitamin D deficiency and oral health: a systematic review of literature.BMC oral health · 2025Pooled it
- Association of vitamin D in individuals with periodontitis: an updated systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Dietary and Nutraceutical Interventions as an Adjunct to Non-Surgical Periodontal Therapy-A Systematic Review.Nutrients · 2023Pooled it
- The Effectiveness of Vitamin D Supplementation in Association with Non-Surgical Periodontal Therapy: A Systematic Review.Dentistry journal · 2026Review
- The Role of Vitamin DNutrients · 2026Review
- Serum levels of vitamin E, vitamin D, and omega-3 fatty acids in patients with generalized chronic periodontitis: A cross-sectional study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Effects of Vitamin D, Melatonin, and Omega-3 Fatty Acids on Periodontal Health: A Narrative Review.Dentistry journal · 2025Review
- Vitamin D binding protein and receptor prevalence in a large population with periodontitis: single nucleotide polymorphism and transcriptomic profiling.BMC oral health · 2024Article
- Association between vitamin D levels and risk of periodontitis in patients with metabolic syndrome.Journal of dental sciences · 2024Article
- Vitamin D Deficiency, Chronic Kidney Disease and Periodontitis.Medicina (Kaunas, Lithuania) · 2024Review
- 1,25-dihydroxyvitamin-DFrontiers in immunology · 2024Article
- Review
- Different doses of vitamin D supplementation to nonsurgical treatment for vitamin-D-insufficient patients with diabetic periodontitis and the effect on gingival BMP-2 levels.The Kaohsiung journal of medical sciences · 2023Article
- Periodontal Disease and Other Adverse Health Outcomes Share Risk Factors, including Dietary Factors and Vitamin D Status.Nutrients · 2023Review
- Anti-Inflammatory Benefits of Food Ingredients in Periodontal Diseases.Pathogens (Basel, Switzerland) · 2023Review
- 25-hydroxyvitamin DFrontiers in immunology · 2023Article
- Oral Health in Breast Cancer Women with Vitamin D Deficiency: A Machine Learning Study.Journal of clinical medicine · 2022Article
- Radiographic Bone Loss and Its Relation to Patient-Specific Risk Factors, LDL Cholesterol, and Vitamin D: A Cross-Sectional Study.Nutrients · 2022Article
- Effect of vitamin DJournal of periodontal research · 2021Article
- Assessment of nutritional status in chronic periodontitis patients: A cross-sectional study.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThis study assessed the effects of weekly vitamin D (VD) supplementation on clinical and biological parameters after scaling and root planning (SRP) in the treatment of periodontitis and served to validate the VD dosage regimen.
methodsIt was a monocentric, randomized, double-blind, placebo-controlled clinical trial with 6 months follow-up. Healthy Caucasian periodontitis patients presenting serum 25(OH) vitamin D3 below 30 ng/mL were randomly allocated to test group (SRP + VD 25,000 international units (IU)/week) or the control group (SRP + placebo).
resultsA total of 59 patients were screened, 27 were included and 26 completed 3 months (M) and 21 completed 6M control. Test (
conclusionsIn this short-term pilot study, no significant differences were observed between two groups. However, supplementation with VD tended to improve the treatment of periodontitis in patients with initial 25(OH) vitamin D3 < 30 ng/mL and proved safe and efficacious. NCT03162406.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.