Evidence map›Paper›PMID 32992653›Full record

ArticleMicroorganisms2020

Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations.

Andrea Quagliariello, Federica Del Chierico, Sofia Reddel, Alessandra Russo, Andrea Onetti Muda, Patrizia D'Argenio, Giulia Angelino, Erminia Francesca Romeo, Luigi Dall'Oglio, Paola De Angelis and 2 more

Abstract read
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrea QuagliarielloArea of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-3941-3684
Federica Del ChiericoArea of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-4204-4736
Sofia ReddelArea of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Alessandra RussoDepartment of Laboratories, Unit of Parasitology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Andrea Onetti MudaDepartment of Laboratories, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Patrizia D'ArgenioAcademic Department of Pediatrics, Unit of Immune and Infectious Diseases, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Giulia AngelinoDigestive Surgery and Endoscopy Unit, Bambino Gesù Children's Hospital IRCCS, 00165 Rome, Italy.
Erminia Francesca RomeoDigestive Surgery and Endoscopy Unit, Bambino Gesù Children's Hospital IRCCS, 00165 Rome, Italy.
Luigi Dall'OglioDigestive Surgery and Endoscopy Unit, Bambino Gesù Children's Hospital IRCCS, 00165 Rome, Italy.
Paola De AngelisDigestive Surgery and Endoscopy Unit, Bambino Gesù Children's Hospital IRCCS, 00165 Rome, Italy.
Lorenza PutignaniDepartment of Laboratories, Unit of Parasitology and Area of Genetics and Rare Diseases, Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0003-0134-2830
All The Other Fmt Opbg Committee Collaborators

Funding

Ministero della Salute 201702P003961MINISTERO DELLA SALUTE 201802G004314
6 · The paper itself

Abstract

Fecal microbiota transplantation (FMT) is a promising strategy in the management of inflammatory bowel disease (IBD). The clinical effects of this practice are still largely unknown and unpredictable. In this study, two children affected by mild and moderate ulcerative colitis (UC), were pre- and post-FMT monitored for clinical conditions and gut bacterial ecology. Microbiota profiling relied on receipts' time-point profiles, donors and control cohorts' baseline descriptions. After FMT, the improvement of clinical conditions was recorded for both patients. After 12 months, the mild UC patient was in clinical remission, while the moderate UC patient, after 12 weeks, had a clinical worsening. Ecological analyses highlighted an increase in microbiota richness and phylogenetic distance after FMT. This increase was mainly due to

Indexed as

fecal microbiota transplantation (FMT)gut bacterial ecologygut microbiotainflammatory bowel disease (IBD)Pediatric Ulcerative Colitis (UC)

Identifiers

PMID32992653
PMCPMC7599854

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.