Evidence map›Paper›PMID 32992569›Full record

ArticleCancers2020

Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.

Michael A Jacobs, Christopher B Umbricht, Vishwa S Parekh, Riham H El Khouli, Leslie Cope, Katarzyna J Macura, Susan Harvey, Antonio C Wolff

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michael A JacobsThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Christopher B UmbrichtSidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Vishwa S ParekhThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Riham H El KhouliDepartment of Radiology and Radiological Sciences, University of Kentucky, Lexington, KY 40536, USA.
Leslie CopeDepartment of Oncology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Katarzyna J MacuraThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Susan HarveyThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Antonio C WolffSidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Johns Hopkins University · USUniversity of Kentucky · US

Funding

Multi-Modality Quantitiative Imaging for Evaluation of Response to Cancer TherapyU01CA140204 · NCI · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, SOLNES, LILJA · 2011 to 2022
$6.1M
Discovery and validation of early molecular breast cancer risk markers in benign breast diseaseR01CA222779 · NCI · JOHNS HOPKINS UNIVERSITY · PI UMBRICHT, CHRISTOPHER B · 2018 to 2023
$2.3M
NCI NIH HHS R01 CA222779NIH HHS 1R01CA190299NIH HHS 5P30CA006973NIH HHS U01CA140204
6 · The paper itself

Abstract

Optimal use of multiparametric magnetic resonance imaging (mpMRI) can identify key MRI parameters and provide unique tissue signatures defining phenotypes of breast cancer. We have developed and implemented a new machine-learning informatic system, termed Informatics Radiomics Integration System (IRIS) that integrates clinical variables, derived from imaging and electronic medical health records (EHR) with multiparametric radiomics (mpRad) for identifying potential risk of local or systemic recurrence in breast cancer patients. We tested the model in patients (

Indexed as

ADC mapbreastcancerdiffusion-weighted imagingDWIinformaticsIRISmachine learningmagnetic resonance imagingmpRadmultiparametric radiomicsOncotypeDXradiomics

Identifiers

PMID32992569
PMCPMC7601838
OpenAlexW3088332058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.