Evidence map›Paper›PMID 32992554›Full record

ReviewBiomolecules2020

Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels.

Trivia Frazier, Andrea Alarcon, Xiying Wu, Omair A Mohiuddin, Jessica M Motherwell, Anders H Carlsson, Robert J Christy, Judson V Edwards, Robert T Mackin, Nicolette Prevost and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Dextran-based stimuli-responsive hydrogels for smart dressings in wound healing.Journal of materials science. Materials in medicine · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Extracellular Vesicle-Based Hydrogels for Wound Healing Applications.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Trivia FrazierObatala Sciences Inc., New Orleans, LA 70148, USA.
Andrea AlarconObatala Sciences Inc., New Orleans, LA 70148, USA.
Xiying WuObatala Sciences Inc., New Orleans, LA 70148, USA.
Omair A MohiuddinPanjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Science, University of Karachi, Karachi 75270, Pakistan.
Jessica M MotherwellWalter Reed National Military Medical Center, Bethesda, MD 29814, USA.
Anders H CarlssonUnited States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA.
Robert J ChristyUnited States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA.
Judson V EdwardsSouthern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USA.
Robert T MackinSouthern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USA.
Nicolette PrevostSouthern Regional Research Center-USDA-ARS, New Orleans, LA 70124, USA.
Elena GlosterDepartment of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA.
Qiang ZhangDepartment of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA.
Guangdi WangDepartment of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA.
Daniel J HayesDepartment of Biomedical Engineering, State College, Pennsylvania State University, Centre County, PA 16802, USA.
Jeffrey M GimbleObatala Sciences Inc., New Orleans, LA 70148, USA.
Southern Regional Research Center · USXavier University of Louisiana · USLaCell (United States) · USUnited States Army Institute of Surgical Research · USPennsylvania State University · USUniversity of Karachi · PKWalter Reed National Military Medical Center · US

Funding

Xavier RCMI Renewal Application-Research Infrastructure CoreU54MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI Guangdi Wang, Christopher Williams · 2019 to 2026
$41.9M
Xavier's RCMI Cancer Research ProgramG12MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI D'AMOUR, GENE, WANG, GUANGDI · 2012 to 2018
$15.7M
NIMHD NIH HHS U54 MD007595
6 · The paper itself

Abstract

Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose-, blood-, and cellulose-derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.

Indexed as

BurnsCell- and Tissue-Based TherapyCelluloseExosomesHumansHydrogelsMesenchymal Stem CellsMesenchymal Stem Cell TransplantationSkinWound HealingCelluloseHydrogelsadipose-derived stromal/stem cells (ASC)bloodburnscelluloseexosomeplateletspressure injurypressure ulcersecretome

Identifiers

PMID32992554
PMCPMC7650547
OpenAlexW3087959668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.