ArticleNutrients2020
Nutrition Mediates the Relationship between Osteosarcopenia and Frailty: A Pathway Analysis.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of the relationship between body composition including muscle, fat, bone, and body water and frailty in Asian residents.Nagoya journal of medical science · 2025Pooled it
- Prevalence and risk factors of osteosarcopenia: a systematic review and meta-analysis.BMC geriatrics · 2023Pooled it
- Possible osteosarcopenia is associated with loss in intrinsic capacity and early cognitive deficits: a longitudinal study of older adults in Singapore.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Frailty and osteosarcopenia in older men: a hidden vulnerability.BMC geriatrics · 2026Article
- Impact of osteosarcopenia in older people on prognosis following major surgery: a scoping review.PeerJ · 2026Article
- Exploring the mediating roles of depression and cognitive function in the association between sarcopenia and frailty: A Cox survival analysis approach.Journal of advanced research · 2025Article
- The association of dietary inflammatory index and osteosarcopenia in Iranian adults: results of iranian multicenter osteoporosis study.Journal of diabetes and metabolic disorders · 2025Article
- Article
- Overlap between Osteosarcopenia and Frailty and their Association with Poor Health Conditions: The Bushehr Elderly Health Program.Annals of geriatric medicine and research · 2024Article
- The efficacy of nutritional screening indexes in predicting the incidence of osteosarcopenia and major osteoporotic fracture in the elderly.Journal of bone and mineral metabolism · 2024Article
- Individual and combined associations of sarcopenia, osteoporosis and obesity with frailty in a multi-ethnic asian older adult population.BMC geriatrics · 2023Article
- The associations of osteoporosis and possible sarcopenia with disability, nutrition, and cognition in community-dwelling older adults.BMC geriatrics · 2023Article
- Features of older community-dwelling adults with osteosarcopenia requiring support or care.Journal of physical therapy science · 2022Article
- Risk Factors of Frailty in Patients with Distal Radius Fractures.Geriatric orthopaedic surgery & rehabilitation · 2022Article
- Nutrition and Muscle Health.Nutrients · 2021Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
Osteosarcopenia is associated with increased risk of adverse outcomes such as falls and fractures. Its association with frailty is less well-described, particularly in independent community-dwelling older adults. Although nutrition plays a crucial role in maintaining bone and muscle health, the complex relationship between osteosarcopenia and nutrition in the pathogenesis of frailty remains to be elucidated. In this cross-sectional analysis of 230 independent, community-dwelling individuals (mean age 67.2 ± 7.4 years), we examined the associations between osteosarcopenia with nutritional status and frailty, and the mediating role of nutrition in the association between osteosarcopenia and frailty. Osteosarcopenia was defined as fulfilling both the Asian Working Group for Sarcopenia 2019 consensus definition (low relative appendicular skeletal muscle mass adjusted for height, in the presence of either of either low handgrip strength or slow gait speed) and T-score ≤ -2.5 SD on bone mineral densitometry. We assessed frailty using the modified Fried criteria and nutrition using the Mini-Nutritional Assessment. We performed multiple linear regression, followed by pathway analysis to ascertain whether nutrition mediates the relationship between osteosarcopenia and frailty. Our study population comprised: 27 (11.7%) osteosarcopenic, 35 (15.2%) sarcopenic, 36 (15.7%) osteoporotic and 132 (57.4%) normal (neither osteosarcopenic, sarcopenic nor osteoporotic). Osteosarcopenia (β = 1.1, 95% CI 0.86-1.4) and sarcopenia (β = 1.1, 95% CI 0.90-1.4) were significantly associated with frailty, but not osteoporosis. Nutrition mediated the association between osteosarcopenia and frailty (indirect effect estimate 0.09, bootstrap 95% CI 0.01-0.22). In conclusion, osteosarcopenia is associated with frailty and poorer nutritional status, with nutrition mediating the association between osteosarcopenia and frailty. Our findings support early nutritional assessment and intervention in osteosarcopenia to mitigate the risk of frailty.
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