ArticleJournal of clinical medicine2020
Optical Coherence Tomography Angiography of Macula and Optic Nerve in Autism Spectrum Disorder: A Pilot Study.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Association between Autism Spectrum Disorder (ASD) and vision problems. A systematic review and meta-analysis.Molecular psychiatry · 2023Pooled it
- A systematic review and meta-analysis on the ocular characteristics in children and adolescents with neurodevelopmental disorders.Scientific reports · 2023Pooled it
- Retinal Microvascular Features Assessed by Optical Coherence Tomography Angiography in Attention Deficit Hyperactivity Disorder.Journal of clinical medicine · 2026Article
- Cognitive function and retinal biomarkers as novel approach to diagnosing and assessing autism spectrum disorder.Scientific reports · 2025Article
- Retinal Optical Coherence Tomography in Bipolar Disorder: A Scoping Review.Neuropsychobiology · 2025Article
- Can optic nerve morphology in children with autism spectrum disorder be associated with atypical visual-sensory behaviors?Frontiers in psychiatry · 2025Article
- Ocular manifestations in autism spectrum disorder.International journal of ophthalmology · 2025Review
- Relationship between autism spectrum disorder and peripapillary intraretinal layer thickness: a pediatric retrospective cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- Retinal Thinning in Adults with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2024Article
- The Use of Optical Coherence Tomography and Electrophysiological Tests in the Early Diagnosis of Inflammatory Changes in the CNS in children with ASD-A Review of Contemporary Literature.International journal of environmental research and public health · 2023Review
- Retinal Structures in Autism Spectrum Disorder: Results from a Case-Control Study.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to compare retinal thicknesses and vascular parameters between autism spectrum disorder (ASD) and neurotypical (NT) individuals. Recruited ASD subjects and age- and sex-matched NT controls underwent 2 optical coherence tomography scans (OCT) (macular cube and optic nerve cube) and 2 OCT angiography (OCTA) scans (macular and optic nerve head (ONH) OCTA) with the device Cirrus 5000 (Zeiss). Concerning OCT, we considered full retina thickness in 9 macular sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) pattern and peripapillary retinal nerve fiber layer (pRNFL) thickness in 4 quadrants and 12 clock-hour sectors. Vessel density and capillary perfusion density in 9 sectors were measured using 6 × 6 mm macular OCTA. Foveal avascular zone (FAZ) parameters were also considered. ONH 4.5 × 4.5 mm OCTA estimated perfusion density and flux index in 4 peripapillary quadrants. Comparisons between groups of all these parameters were performed. ASD subjects showed higher ONH perfusion density and lower ONH flux index at the peripapillary inferior quadrant when compared with NT individuals (
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Registered trials
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