ArticleBrain sciences2020
IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier.
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In one paragraph
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Association between periodontal disease and Alzheimer's disease: a scoping review.Frontiers in aging neuroscience · 2025Pooled it
- How Periodontitis or Periodontal Bacteria Can Influence Alzheimer's Disease Features? A Systematic Review of Pre-Clinical Studies.Journal of Alzheimer's disease : JAD · 2023Pooled it
- Chronic Paraquat Neurotoxicity and Dopaminergic Degeneration: A Mechanistic Review.Chemistry & biodiversity · 2026Review
- Neurological impairments in Duchenne muscular dystrophy: A comprehensive review.Acta neurologica Belgica · 2026Review
- Blood IL-6 is a critical trigger of depressive symptoms in a mouse model for human atopic dermatitis.Translational psychiatry · 2026Article
- Periodontitis-induced cardiovascular changes and the mitigating effects of non-surgical periodontal treatment in a rat model.BMC oral health · 2026Article
- Distinct neural substrates of disease severity and cognitive impairment in COPD: a multimodal MRI study.BMC medical imaging · 2026Article
- Oral-Systemic Links: A Narrative Review of the Role of Periodontitis in Alzheimer's Disease Development.Cureus · 2026Review
- Heart-Brain Axis in Viral Myocarditis: Shared Cytokine Pathways, Blood-Brain Barrier Crosstalk, and Neuroinflammatory Consequences.International journal of molecular sciences · 2026Review
- Review
- Oral health conditions and domain-specific cognitive decline in older adults: evidence from the Baltimore Longitudinal Study of Aging 2005-2024.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Chronic periodontitis and systemic inflammation in the elderly: implications for neurodegeneration.Journal of neuroinflammation · 2026Review
- Longitudinal association between oral health and dementia among older adults: evidence from the Korean longitudinal study of ageing.BMC geriatrics · 2026Article
- Periodontitis and Systemic Health: An Interconnected Relationship.Advances in experimental medicine and biology · 2026Review
- Integrated transcriptomic profiling combined withFrontiers in aging neuroscience · 2026Article
- Review
- Periodontitis and Parkinson's disease: a narrative review of associations, proposed mechanisms, and clinical considerations.Frontiers in oral health · 2026Review
- Association of weight-adjusted waist index with motoric cognitive risk syndrome in Chinese adults Aged ≥ 60 years.Lipids in health and disease · 2025Article
- Evaluating dental health in patients with different severity of Parkinson's disease: a cross-sectional study.BMC oral health · 2025Article
- Unraveling brain aging through the lens of oral microbiota.Neural regeneration research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Daisuke FurutamaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Shinji MatsudaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.ORCID 0000-0002-4281-3216
Yosuke YamawakiDepartment of Advanced Pharmacology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku Fukuoka 815-8511, Japan.ORCID 0000-0002-7247-8295
Saki HatanoDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Ai OkanobuDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Takumi MemidaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Hiroshi OueDepartment of Advanced Prosthodontics, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.ORCID 0000-0003-2995-090X
Tsuyoshi FujitaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Kazuhisa OuharaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.ORCID 0000-0001-6796-884X
Mikihito KajiyaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.ORCID 0000-0001-6652-0007
Noriyoshi MizunoDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Takashi KanematsuLaboratory of Cell Biology and Pharmacology, Kyushu University Faculty of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.ORCID 0000-0001-8592-0831
Kazuhiro TsugaDepartment of Advanced Prosthodontics, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Hidemi KuriharaDepartment of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Hiroshima University · JPDaiichi University of Pharmacy · JPKyushu University · JP
Funding
Japan Society for the Promotion of Science 19K10130
Abstract
PubMed holds no abstract for this paper.
Indexed as
BBB permeabilityneuroinflammationperiodontal inflammationserum IL-6
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.