Evidence map›Paper›PMID 32992455›Full record

ArticleMarine drugs2020

A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway.

Lan Wang, Yun Huang, Cui-Hong Huang, Jian-Chen Yu, Ying-Chun Zheng, Yan Chen, Zhi-Gang She, Jie Yuan

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lan WangDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Yun HuangDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Cui-Hong HuangSchool of Medicine & Health Care, Shunde Polytechnic, Shunde 528333, China.
Jian-Chen YuDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Ying-Chun ZhengDepartment of Pathogen Biology and Immunology, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Yan ChenSchool of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
Zhi-Gang SheSchool of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.ORCID 0000-0002-0130-6701
Jie YuanDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Sun Yat-sen University · CNGuangdong Pharmaceutical University · CNShunde Polytechnic · CN

Funding

the Guangdong MEPP Fund GDOE [2019]A21the Key Project of Natural Science Foundation of Guangdong Province 2016A030311026the Natural science Foundation of Guangdong Province, China 2017A030313549the Traditional Chinese Medicine of Guangdong Province 20181300
6 · The paper itself

Abstract

Ascomylactam A was reported for the first time as a new 13-membered-ring macrocyclic alkaloid in 2019 from the mangrove endophytic fungus

Indexed as

AlkaloidsAnimalsAntineoplastic AgentsAscomycotaCell Line, TumorCell ProliferationG1 Phase Cell Cycle CheckpointsHumansInhibitory Concentration 50Lung NeoplasmsMaleMiceMice, Inbred BALB CMice, NudeProto-Oncogene Proteins c-aktReactive Oxygen SpeciesAlkaloidsAntineoplastic AgentsProto-Oncogene Proteins c-aktReactive Oxygen SpeciesRetinoblastoma ProteinAktascomylactam Acell cycle arrestcell proliferationlung cancerRbROS

Identifiers

PMID32992455
PMCPMC7599880
OpenAlexW3087817660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.