Evidence map›Paper›PMID 32992199›Full record

SynthesisJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2020

Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis.

Mai Yamakawa, Toshiki Kuno, Takahisa Mikami, Hisato Takagi, Gary Gronseth

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  6. Stroke and COVID-19: An Umbrella Review.Archives of academic emergency medicine · 2024
    Review
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  20. Reversible Cerebral Vasoconstriction Syndrome in Patients with Coronavirus Disease: A Multicenter Case Series.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mai YamakawaDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Toshiki KunoDepartment of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, First Avenue, 16th street, New York 10003, NY, USA. Electronic address: Toshiki.Kuno@mountsinai.org.
Takahisa MikamiDepartment of Neurology, Tufts Medical Center, Boston, MA, USA.
Hisato TakagiDivision of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan.
Gary GronsethUniversity of Kansas Medical Center, Department of Neurology, Kansas City, KS, USA.
University of Kansas Medical Center · USMount Sinai Beth Israel · USShizuoka Medical Center · JPTufts Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) potentially increases the risk of thromboembolism and stroke. Numerous case reports and retrospective cohort studies have been published with mixed characteristics of COVID-19 patients with stroke regarding age, comorbidities, treatment, and outcome. We aimed to depict the frequency and clinical characteristics of COVID-19 patients with stroke.

methodsPubMed and EMBASE were searched on June 10, 2020, to investigate COVID-19 and stroke through retrospective cross-sectional studies, case series/reports according to PRISMA guidelines. Study-specific estimates were combined using one-group meta-analysis in a random-effects model.

results10 retrospective cohort studies and 16 case series/reports were identified including 183 patients with COVID-19 and stroke. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1% ([95% confidential interval (CI)]: [0.6-1.6], I

conclusionsThis systematic review assessed the frequency and clinical characteristics of stroke in COVID-19 patients. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1% and associated with older age and stroke risk factors. Frequent cryptogenic stroke and elevated d-dimer level support increased risk of thromboembolism in COVID-19 associated with high mortality. Further study is needed to elucidate the pathophysiology and prognosis of stroke in COVID-19 to achieve most effective care for this population.

Indexed as

AgedAged, 80 and overAge FactorsBiomarkersCOVID-19FemaleFibrin Fibrinogen Degradation ProductsHumansMaleMiddle AgedPrognosisRisk AssessmentRisk FactorsStrokeThromboembolismBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DCOVID-19Meta-analysisSARS-CoV2strokeSystematic review

Identifiers

PMID32992199
PMCPMC7456266
OpenAlexW3080556350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.