Evidence map›Paper›PMID 32991982›Full record

ArticleJournal of cardiac failure2021

Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients With Coronavirus Disease-19.

Erin Goerlich, Nisha A Gilotra, Anum S Minhas, Nicole Bavaro, Allison G Hays, Oscar H Cingolani

Abstract read
In one paragraph

Article in Journal of cardiac failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Multimodality Cardiac Imaging in COVID-19 Infection.Medicina (Kaunas, Lithuania) · 2023
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. COVID and Cardiovascular Disease: What We Know in 2021.Current atherosclerosis reports · 2021
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erin GoerlichDivision of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
Nisha A GilotraDivision of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
Anum S MinhasDivision of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
Nicole BavaroDivision of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
Allison G HaysDivision of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
Oscar H CingolaniDivision of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland. Electronic address: ocingol1@jhmi.edu.

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
Emerging factors in the pathophysiology of endothelial dysfunction in HIV+ womenR01HL147660 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HAYS, ALLISON G · 2019 to 2023
$1.4M
NHLBI NIH HHS R01 HL147660NHLBI NIH HHS T32 HL007024NHLBI NIH HHS T32 HL007227
6 · The paper itself

Abstract

backgroundCoronavirus disease-19 (COVID-19) has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain on speckle-tracking echocardiography in hospitalized patients with COVID-19 and subsequently aimed to identify characteristics of affected patients. We hypothesized that patients with COVID-19 with reduced basal LV strain would demonstrate elevated cardiac biomarkers. METHODS AND

resultEighty-one consecutive patients with COVID-19 underwent speckle-tracking echocardiography. Those with poor quality speckle-tracking echocardiography (n = 2) or a known LV ejection fraction of <50% (n = 4) were excluded. Patients with an absolute value basal longitudinal strain of <13.9% (2 standard deviations below normal) were designated as cases (n = 39); those with a basal longitudinal strain of ≥13.9% were designated as controls (n = 36). Demographics and clinical variables were compared. Of 75 included patients (mean age 62 ± 14 years, 41% women), 52% had reduced basal strain. Cases had higher body mass index (median 34.1; interquartile range 26.5-37.9 kg/m

conclusionsReduced basal LV strain is common in patients with COVID-19. Patients with hypertension, diabetes, obesity, and Black race were more likely to have reduced basal strain. Further investigation into the significance of this strain pattern is warranted.

Indexed as

AgedCOVID-19EchocardiographyFemaleHeart FailureHospitalizationHumansMaleMiddle AgedVentricular Dysfunction, LeftCOVID-19, strainEchocardiographymyocardial dysfunction

Identifiers

PMID32991982
PMCPMC7521413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.