Evidence map›Paper›PMID 32991934›Full record

ArticleExperimental neurology2021

A micro-LED implant and technique for optogenetic stimulation of the rat spinal cord.

S E Mondello, B D Pedigo, M D Sunshine, A E Fischedick, P J Horner, C T Moritz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
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  6. Review
  7. Optogenetics in primate cortical networks.Frontiers in neuroanatomy · 2023
    Article
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  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

S E MondelloDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington 98195, USA; Center for Neurotechnology, Seattle, Washington 98195, USA.
B D PedigoDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington 98195, USA.
M D SunshineDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington 98195, USA.
A E FischedickDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington 98195, USA.
P J HornerCenter for Neuroregeneration, Department of Neurological Surgery, Houston Methodist Research Institute, Houston, TX 77030, USA.
C T MoritzDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington 98195, USA; University of Washington Institute for Neuroengineering, University of Washington, Seattle, Washington 98195, USA; Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA; Graduate Program in Neuroscience, University of Washington, Seattle, Washington 98195, USA; Center for Neurotechnology, Seattle, Washington 98195, USA; Department of Electrical & Computer Engineering, University of Washington, Seattle, Washington 98195, USA. Electronic address: ctmoritz@uw.edu.
University of Washington · USNeurological Surgery · US

Funding

Optogenetics to improve hand function after spinal cord injury.R01NS115025 · NINDS · UNIVERSITY OF WASHINGTON · PI ANIKEEVA, POLINA O, MORITZ, CHET T. · 2020 to 2023
$2.4M
NINDS NIH HHS R01 NS115025
6 · The paper itself

Abstract

To date, relatively few studies have used optogenetic stimulation to address basic science and therapeutic questions within the spinal cord. Even less have reported optogenetic stimulation in the rat spinal cord. This is likely due to a lack of accessible optogenetic implants. The development of a device that can be fabricated and operated by most laboratories, requiring no special equipment, would allow investigators to begin dissecting the functions of specific neuronal cell-types and circuitry within the spinal cord, as well as investigate therapies for spinal ailments like spinal cord injury. Here, we describe a long-term implantable μLED device designed for optogenetic stimulation of the spinal cord in awake, freely moving rats that is simple enough to be fabricated, implanted and operated by most laboratories. This device, which sits above the dorsal cord, can induce robust movements for at least 6 weeks without causing physical or thermal damage to the underlying spinal cord. In this regard, the presented μLED device could help tease apart the complexities of the spinal cord and uncover potential future therapeutics.

Indexed as

Prostheses and ImplantsAnimalsBody TemperatureCalibrationDependovirusEquipment DesignImmunohistochemistryMovementOptogeneticsPhotic StimulationRatsRats, Long-EvansSpinal CordSpinal Cord InjuriesSpinal Cord StimulationAAV transductionNeural devicesOptogenetic spinal stimulationRat spinal cordμLED implant

Identifiers

PMID32991934
PMCPMC8284995
OpenAlexW3088895496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.