ArticleJornal de pediatria
Performance of prognostic markers in pediatric sepsis.
Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.Critical care medicine · 2022Pooled it
- Early recognition and bundle-based management of pediatric sepsis in the emergency department: a narrative review.Translational pediatrics · 2026Review
- Diagnostic utility of serum ferritin in culture proven bacterial infection: an observational study.BMC infectious diseases · 2026Observational
- Role of biomarkers in pediatric sepsis: What evidence says?World journal of clinical pediatrics · 2026Review
- Short-term risk stratification using parallel admission and reassessment features in PICU patients with infection.Frontiers in pediatrics · 2026Article
- Admission Serum Ferritin Levels as a Predictor of Severe Disease in Hospitalized Pediatric Patients in Mexico.Mediators of inflammation · 2026Observational
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- Advances and Challenges in Pediatric Sepsis Diagnosis: Integrating Early Warning Scores and Biomarkers for Improved Prognosis.Biomolecules · 2025Review
- Article
- Article
- Hierarchical Capability in Distinguishing Severities of Sepsis via Serum Lactate: A Network Meta-Analysis.Biomedicines · 2024Review
- The independent predictive value of admission serum ferritin concentration for prognosis in elderly patients with community-acquired pneumonia in the emergency department.Frontiers in cellular and infection microbiology · 2024Article
- The predictive value of peripheral blood cell mitochondrial gene expression in identifying the prognosis in pediatric sepsis at preschool age.Frontiers in cellular and infection microbiology · 2024Article
- Ferritin in pediatric critical illness: a scoping review.Clinical and experimental pediatrics · 2023Article
- Refining empiric subgroups of pediatric sepsis using machine-learning techniques on observational data.Frontiers in pediatrics · 2023Review
- Decreased circulating levels of free triiodothyronine in Sepsis children and correlation analysis.BMC pediatrics · 2022Article
- Role of PIM2 in acute lung injury induced by sepsis.Experimental and therapeutic medicine · 2022Article
- Predicting mortality in pediatric sepsis: A laudable but elusive goal.Jornal de pediatriaArticle
- Merging Pediatric Index of Mortality (a physiologic instability measure), lactate, and Systemic Inflammation Mortality Risk to better predict outcome in pediatric sepsis.Jornal de pediatriaArticle
- PIM2, lactate, and trauma score to predict mortality in critically ill pediatric trauma patients.Jornal de pediatriaArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the prognostic performance of the Pediatric Index of Mortality 2 (PIM2), ferritin, lactate, C-reactive protein (CRP), and leukocytes, alone and in combination, in pediatric patients with sepsis admitted to the pediatric intensive care unit (PICU).
methodsA retrospective study was conducted in a PICU in Brazil. All patients aged 6 months to 18 years admitted with a diagnosis of sepsis were eligible for inclusion. Those with ferritin and C-reactive protein measured within 48h and lactate and leukocytes within 24h of admission were included in the prognostic performance analysis.
resultsOf 350 eligible patients with sepsis, 294 had undergone all measurements required for analysis and were included in the study. PIM2, ferritin, lactate, and CRP had good discriminatory power for mortality, with PIM2 and ferritin being superior to CRP. The cutoff values for PIM2 (> 14%), ferritin (> 135ng/mL), lactate (> 1.7mmol/L), and CRP (> 6.7mg/mL) were associated with mortality. The combination of ferritin, lactate, and CRP had a positive predictive value of 43% for mortality, similar to that of PIM2 alone (38.6%). The combined use of the three biomarkers plus PIM2 increased the positive predictive value to 76% and accuracy to 0.945.
conclusionsPIM2, ferritin, lactate, and CRP alone showed good prognostic performance for mortality in pediatric patients older than 6 months with sepsis. When combined, they were able to predict death in three-fourths of the patients with sepsis. Total leukocyte count was not useful as a prognostic marker.
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