ArticleAmerican journal of respiratory and critical care medicine2021
Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 311 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
311citing papers in PubMed, 1 pooled it
29.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
311 citing papers in PubMed, 1 synthesis or guideline pooled it, 501 citations in OpenAlex.
- Use quercetin for pulmonary fibrosis: a preclinical systematic review and meta-analysis.Inflammopharmacology · 2025Pooled it
- Prophylactic quercetin administration attenuates pulmonary fibrosis via ferroptosis-resistant priming of alveolar epithelial cells.Redox report : communications in free radical research · 2026Article
- The METTL3/LOXL2 axis participates in aberrant epithelial-fibroblast crosstalk and induces oral submucous fibrosis in rats.Molecular and cellular biochemistry · 2026Article
- Targeting the CD4Molecular biomedicine · 2026Article
- Beryllium Sulfate-Induced Cellular Senescence via the IL-6/STAT3 Pathway to Promote Pulmonary Fibrosis.Journal of applied toxicology : JAT · 2026Article
- A compendium of circulating biomarkers of senescence in humans: Insights on mechanistic impact across health domains and modulation by therapeutic interventions.Ageing research reviews · 2026Review
- Alveolar epithelial depletion of βPAK-interacting exchange factor drives spontaneous pulmonary fibrosis by impairing stemness.Signal transduction and targeted therapy · 2026Article
- Fuelling repair: metabolic regulation of alveolar type 2 cell fate in lung regeneration and disease.Disease models & mechanisms · 2026Review
- Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review).International journal of molecular medicine · 2026Review
- Multi-omics insights into the mechanisms and prognosis of IPF.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2026Review
- Telomere dysfunction and mucociliary impairment drive idiopathic pulmonary fibrosis susceptibility: insights from a Sardinian whole-exome study.BMJ open respiratory research · 2026Article
- Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis.bioRxiv : the preprint server for biology · 2026Article
- Cellular hallmarks and aging clock of the human lung parenchyma.Nature communications · 2026Article
- Atg5 deficiency alters myofibroblast accumulation and alveolar regeneration in lung fibrosis.Stem cell reports · 2026Article
- Convergent Microenvironment Linking Idiopathic Pulmonary Fibrosis and Lung Cancer.Expert reviews in molecular medicine · 2026Review
- Epigenetic dynamics of cellular senescence: From mechanistic insights to precision senotherapy.Chinese medical journal · 2026Review
- Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers.MedComm · 2026Review
- Combination of Ophiopogonin D, Ginsenoside Rg1, and Ginsenoside Rg3 ameliorates idiopathic pulmonary fibrosis via inhibiting type 2 alveolar epithelial cell senescence and epithelial-mesenchymal transition.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Cellular Senescence: Emerging Therapeutic Target for Idiopathic Pulmonary Fibrosis Pathogenic Mechanisms and Therapeutic Strategies.Biomolecules & therapeutics · 2026Review
- Ageing-associated regenerative failure in the lung: stem cell senescence and transitional cell persistence in idiopathic pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2026Review
251 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
15 authors at 4 institutions in 2 countries.
Changfu YaoWomen's Guild Lung Institute, Department of Medicine.
Xiangrong GuanWomen's Guild Lung Institute, Department of Medicine.
Gianni CarraroWomen's Guild Lung Institute, Department of Medicine.
Tanyalak ParimonWomen's Guild Lung Institute, Department of Medicine.
Xue LiuWomen's Guild Lung Institute, Department of Medicine.
Guanling HuangWomen's Guild Lung Institute, Department of Medicine.
Apoorva MulayWomen's Guild Lung Institute, Department of Medicine.
Harmik J SoukiasianDivision of Thoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
Gregory DavidDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York University, New York, New York; and.
Stephen S WeigtDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.
John A BelperioDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.
Peter ChenWomen's Guild Lung Institute, Department of Medicine.
Dianhua JiangWomen's Guild Lung Institute, Department of Medicine.ORCID 0000-0002-4508-3829
Paul W NobleWomen's Guild Lung Institute, Department of Medicine.
Barry R StrippWomen's Guild Lung Institute, Department of Medicine.
Institute for Women's Policy Research · USUniversity of California, Los Angeles · USCedars-Sinai Medical Center · USNew York University · US
Funding
Role of Surfactant Proteins in Mediating Noninfectious Inflammatory and FibroproP01HL108793 · NHLBI · DUKE UNIVERSITY · PI BELPERIO, JOHN A · 2012 to 2022
$21.3MThe Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1MLung Repair and Regeneration Consortium Administrative Coordinating CenterU01HL110967 · NHLBI · DUKE UNIVERSITY · PI PALMER, SCOTT M · 2012 to 2016
$6.2MMolecular Regulation of Progressive Pulmonary FibrosisR35HL150829 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Paul Wesley Noble · 2020 to 2026
$5.7MEpithelial progenitor cells for lung repair and regenerationR01HL135163 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI STRIPP, BARRY R · 2017 to 2020
$2.7MMultidisciplinary Pulmonary Research Training ProgramT32HL134637 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI NOBLE, PAUL WESLEY · 2017 to 2021
$1.3MSyndecan-1 regulation of lung fibrosisK08HL141590 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI PARIMON, TANYALAK · 2020 to 2024
$854kNCATS NIH HHS KL2 TR001882NHLBI NIH HHS K08 HL141590NHLBI NIH HHS P01 HL108793NHLBI NIH HHS R01 HL135163NHLBI NIH HHS R35 HL150829NHLBI NIH HHS T32 HL134637NHLBI NIH HHS U01 HL110967
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cellular SenescenceAgedAged, 80 and overAgingAlveolar Epithelial CellsFemaleHumansIdiopathic Pulmonary FibrosisMalealveolar type 2 cellscellular senescencepulmonary fibrosis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.