ArticleAnnals of clinical and translational neurology2020
White matter and neurite morphology differ in psychogenic nonepileptic seizures.
Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Exploratory study of peripheral immune changes associated with diffusion MRI multi-compartment model in temporal lobe epilepsy.Epilepsia · 2025Article
- Neurobehavioral therapy in functional seizures: Investigation of mechanism of action with resting-state functional magnetic resonance imaging.Epilepsia · 2025Article
- Brain network entropy, depression, and quality of life in people with traumatic brain injury and seizure disorders.Epilepsia open · 2024Article
- Brain temperature and free water increases after mild COVID-19 infection.Scientific reports · 2024Article
- Glymphatic System Activity and Brain Morphology in Patients With Psychogenic Non-epileptic Seizures.Cureus · 2024Article
- Mendelian randomization analyses support causal relationships between systemic lupus erythematosus and brain imaging-derived phenotypes.Frontiers in neurology · 2024Article
- White Matter Structural Connectivity and Its Impact on Psychogenic Non-Epileptic Seizures: An Evidence-Based Review.Neuropsychiatric disease and treatment · 2023Review
- Neurite Orientation Dispersion and Density Imaging in Psychiatric Disorders: A Systematic Literature Review and a Technical Note.Biological psychiatry global open science · 2023Review
- White matter microstructure and serum biomarkers of inflammation in psychogenic non-epileptic seizures.NeuroImage. Clinical · 2023Article
- Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy.Neuropsychiatric disease and treatment · 2023Article
- Article
- Recent Advances in Neuroimaging of Epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study.Human brain mapping · 2021Article
- Validation of a predictive calculator to distinguish between patients presenting with dissociative versus epileptic seizures.Epilepsy & behavior : E&B · 2021Article
- Structural and Functional Default Mode Network Connectivity and Antipsychotic Treatment Response in Medication-Naïve First Episode Psychosis Patients.Schizophrenia bulletin open · 2021Article
- Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda.NeuroImage. Clinical · 2021Review
- Neuroinflammation as a pathophysiological factor in the development and maintenance of functional seizures: A hypothesis.Epilepsy & behavior reports · 2021Article
- The Molecular Dichotomy Between Epileptic and Functional Seizures.Epilepsy currentsArticle
- A survey about laughter upon viewing functional seizures.Frontiers in neurologyArticle
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo further evaluate the relationship between the clinical profiles and limbic and motor brain regions and their connecting pathways in psychogenic nonepileptic seizures (PNES). Neurite Orientation Dispersion and Density Indices (NODDI) multicompartment modeling was used to test the relationships between tissue alterations in patients with traumatic brain injury (TBI) and multiple psychiatric symptoms.
methodsThe sample included participants with prior TBI (TBI; N = 37) but no PNES, and with TBI and PNES (TBI + PNES; N = 34). Participants completed 3T Siemens Prisma MRI high angular resolution imaging diffusion protocol. Statistical maps, including fractional anisotropy (FA), mean diffusivity (MD), neurite dispersion [orientation dispersion index (ODI)] and density [intracellular volume fraction (ICVF), and free water (i.e., isotropic) volume fraction (V-ISO)] signal intensity, were generated for each participant. Linear mixed-effects models identified clusters of between-group differences in indices of white matter changes. Pearson's r correlation tests assessed any relationship between signal intensity and psychiatric symptoms.
resultsCompared to TBI, TBI + PNES revealed decreases in FA, ICVF, and V-ISO and increases in MD for clusters within cingulum bundle, uncinate fasciculus, fornix/stria terminalis, and corticospinal tract pathways (cluster threshold α = 0.05). Indices of white matter changes for these clusters correlated with depressive, anxiety, PTSD, psychoticism, and somatization symptom severity (FDR threshold α = 0.05). A follow-up within-group analysis revealed that these correlations failed to reach the criteria for significance in the TBI + PNES group alone.
interpretationThe results expand support for the hypothesis that alterations in pathways comprising the specific PNES network correspond to patient profiles. These findings implicate myelin-specific changes as possible contributors to PNES, thus introducing novel potential treatment targets.
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