Evidence map›Paper›PMID 32991741›Full record

ArticleThe Journal of physiology2021

A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction.

Juan J Ferreira, Germán Pequera, Bradley S Launikonis, Eduardo Ríos, Gustavo Brum

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Competing effects of activation history on force and cytosolic CaPflugers Archiv : European journal of physiology · 2025
    Article
  2. Article
  3. Quantal Properties of Voltage-Dependent CaThe Journal of membrane biology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Juan J FerreiraLaboratorio de Biofísica del Músculo, Departamento de Biofísica, Facultad de Medicina, Montevideo, Uruguay.ORCID 0000-0001-8175-9067
Germán PequeraLaboratorio de Biofísica del Músculo, Departamento de Biofísica, Facultad de Medicina, Montevideo, Uruguay.
Bradley S LaunikonisSchool of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0003-0700-4867
Eduardo RíosSection of Cellular Signaling, Department of Physiology and Biophysics, Rush University, Chicago, IL, USA.ORCID 0000-0003-0985-8997
Gustavo BrumLaboratorio de Biofísica del Músculo, Departamento de Biofísica, Facultad de Medicina, Montevideo, Uruguay.ORCID 0000-0002-6459-5934
Universidad de Montevideo · UYQueensland University of Technology · AURush University · US

Funding

Mechanisms of couplon-linked skeletal muscle myopathiesR01AR072602 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L, HORRIGAN, FRANK T · 2018 to 2022
$3.3M
The HH: A Large Cohort of Patients with Congenital Myopathies of Uncertain EtiologyR01AR071381 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI FILL, MICHAEL, RIAZI, SHEILA · 2017 to 2021
$2.7M
Dual Confocal Microscopic ScannerS10RR024707 · NCRR · RUSH UNIVERSITY MEDICAL CENTER · PI RIOS, EDUARDO · 2008 to 2008
$500k
NCRR NIH HHS S1055024707NCRR NIH HHS S10 RR024707NIAMS NIH HHS R01 AR071381NIAMS NIH HHS R01 AR072602NIH HHS R01AR072602
6 · The paper itself

Abstract

key pointsAccumulation of inorganic phosphate (P ABSTRACT: Fatiguing exercise causes hydrolysis of phosphocreatine, increasing the intracellular concentration of inorganic phosphate (P

Indexed as

CalciumPhosphatesCalcium SignalingChloride ChannelsChloridesMuscle ContractionRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumCalciumChloride ChannelsChloridesPhosphatesRyanodine Receptor Calcium Release Channel9-anthracenecarboxylic acidchloride channelfatigueinorganic phosphatesarcoplasmic reticulumskeletal muscle

Identifiers

PMID32991741
PMCPMC7775353
OpenAlexW3089838839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.