Evidence map›Paper›PMID 32991672›Full record

ReviewAnesthesiology2021

Perioperative Opioid Administration.

Harsha Shanthanna, Karim S Ladha, Henrik Kehlet, Girish P Joshi

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 126 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06291363 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Impact of Continuous Intraoperative Administration of Esmolol on Nociception Level-guided Control of Nociception. The EsmoNOL Randomized Controlled Trial

TypeinterventionalSponsorCiusss de L'Est de l'Île de MontréalRan2024 to 2025Enrolled64ConditionsOpioid Use, Unspecified, Anesthesia, Nociceptive PainArmsEsmolol Hydrochloride, Saline
NCT07269106 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety of Anrikefon for Postoperative Analgesia in Ophthalmic Surgery: A Multicenter, Randomized, Parallel-Control, Non-Inferiority Trial

TypeinterventionalSponsorZhongshan Ophthalmic Center, Sun Yat-sen UniversityRan2026 to 2027Enrolled204ConditionsOphthalmic Surgery, Postoperative Pain Management, Opioid AnalgesiaArmsAnrikefon, Nalbuphine
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Harsha Shanthanna
Karim S Ladha
Henrik Kehlet
Girish P Joshi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioids form an important component of general anesthesia and perioperative analgesia. Discharge opioid prescriptions are identified as a contributor for persistent opioid use and diversion. In parallel, there is increased enthusiasm to advocate opioid-free strategies, which include a combination of known analgesics and adjuvants, many of which are in the form of continuous infusions. This article critically reviews perioperative opioid use, especially in view of opioid-sparing versus opioid-free strategies. The data indicate that opioid-free strategies, however noble in their cause, do not fully acknowledge the limitations and gaps within the existing evidence and clinical practice considerations. Moreover, they do not allow analgesic titration based on patient needs; are unclear about optimal components and their role in different surgical settings and perioperative phases; and do not serve to decrease the risk of persistent opioid use, thereby distracting us from optimizing pain and minimizing realistic long-term harms.

Indexed as

Analgesics, OpioidHumansOpioid-Related DisordersPerioperative CarePostoperative PainAnalgesics, Opioid

Identifiers

PMID32991672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.