Evidence map›Paper›PMID 32991336›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2020

HIV Stigma and Viral Suppression Among People Living With HIV in the Context of Universal Test and Treat: Analysis of Data From the HPTN 071 (PopART) Trial in Zambia and South Africa.

James R Hargreaves, Triantafyllos Pliakas, Graeme Hoddinott, Tila Mainga, Constance Mubekapi-Musadaidzwa, Deborah Donnell, Estelle Piwowar-Manning, Yaw Agyei, Nomhle F Mandla, Rory Dunbar and 10 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07221201 (Reducing the Intersecting Stigmas of HIV, Violence Victimization, and Mental Health), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07221201 nacompletednot on this mapstarted 2025, after this paper: background citation

Reducing the Intersecting Stigmas of HIV, Violence Victimization, and Mental Health: a Randomized Controlled Pilot Integrating Project YES! Youth Engaging for Success With WHO-Endorsed Mental Health Approaches Among Youth Living With HIV in Ndola, Zambia

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2025 to 2026Enrolled323ConditionsHIV - Human Immunodeficiency Virus, Mental Health, Anxiety, Depression in AdolescenceArmsProject YES+ intervention arm
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. Correlates of Viral Suppression in Adolescents With HIV Taking Antiretroviral Therapy in Mozambique: Results of a Multicenter Cross-Sectional Survey.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

James R HargreavesDepartment of Public Health, Environments and Society, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Triantafyllos PliakasDepartment of Public Health, Environments and Society, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Graeme HoddinottDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Tila MaingaZambart, School of Medicine, University of Zambia, Lusaka, Zambia.
Constance Mubekapi-MusadaidzwaDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Deborah DonnellSCHARP, Seattle, WA.
Estelle Piwowar-ManningJohns Hopkins University School of Medicine, Baltimore, MD.
Yaw AgyeiJohns Hopkins University School of Medicine, Baltimore, MD.
Nomhle F MandlaDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Rory DunbarDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
David MacleodDepartment of Public Health, Environments and Society, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Sian FloydDepartment of Public Health, Environments and Society, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Peter BockDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Sarah FidlerImperial College NIHR BRC, Imperial College London, London, United Kingdom; and.
Richard J HayesDepartment of Public Health, Environments and Society, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Janet SeeleyDepartment of Public Health, Environments and Society, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Anne StanglInternational Center for Research on Women, Washington, DC.
Virginia BondDepartment of Public Health, Environments and Society, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Helen AylesDepartment of Public Health, Environments and Society, London School of Hygiene and Tropical Medicine, London, United Kingdom.
HPTN 071 (PopART) Study Team

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
Department of HealthMedical Research Council MR/R010161/1NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068619PEPFAR
6 · The paper itself

Abstract

backgroundThe impact of HIV stigma on viral suppression among people living with HIV (PLHIV) is not well characterized.

settingTwenty-one communities in Zambia and South Africa, nested within the HPTN 071 (PopART) trial.

methodsWe analyzed data on viral suppression (<400 copies HIV RNA/mL) among 5662 laboratory-confirmed PLHIV aged 18-44 years who were randomly sampled within the PopART trial population cohort 24 months after enrolment (PC24). We collected data on experiences and internalization of stigma from those PLHIV who self-reported their HIV status (n = 3963/5662) and data on perceptions of stigma from a 20% random sample of all PLHIV (n = 1154/5662). We also measured stigma at the community-level among PLHIV, community members, and health workers. We analyzed the association between individual- and community-level measures of HIV stigma and viral suppression among PLHIV, adjusting for confounding.

resultsOf all 5662 PLHIV, 69.1% were virally suppressed at PC24. Viral suppression was highest among those 3963 cohort participants who self-reported living with HIV and were on ART (88.3%), and lower among those not on treatment (37.5%). Self-identifying PLHIV who reported internalized stigma were less likely to be virally suppressed (75.0%) than those who did not (80.7%; adjusted risk ratio, 0.94 95% CI: 0.89 to 0.98). Experiences, perceptions, and community-level measures of stigma were not associated with viral suppression.

conclusionInternalized stigma among PLHIV was associated with a lower level of viral suppression; other dimensions of stigma were not. Stigma reduction approaches that address internalized stigma should be an integral component of efforts to control the HIV epidemic.

Indexed as

Social StigmaAdolescentAdultAnti-HIV AgentsDrug MonitoringFemaleHIV InfectionsHumansMaleMedication AdherenceSouth AfricaViral LoadYoung AdultZambiaAnti-HIV Agents

Identifiers

PMID32991336
PMCPMC7654947

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.