Evidence map›Paper›PMID 32991265›Full record

ReviewAnnual review of virology2020

Plant Viruses and Bacteriophage-Based Reagents for Diagnosis and Therapy.

Sourabh Shukla, He Hu, Hui Cai, Soo-Khim Chan, Christine E Boone, Veronique Beiss, Paul L Chariou, Nicole F Steinmetz

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Design andMaterials today. Bio · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals.Bioengineering (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Biomaterial-Based In Situ Cancer Vaccines.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Plant-Derived Human Vaccines: Recent Developments.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sourabh ShuklaDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
He HuDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Hui CaiDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Soo-Khim ChanDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Christine E BooneDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Veronique BeissDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Paul L ChariouDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
Nicole F SteinmetzDepartment of NanoEngineering, University of California, San Diego, La Jolla, California 92093, USA.
University of California, San Diego · US

Funding

Dual-pronged nano-drug delivery using plant virus-like particles.R01CA224605 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Nicole Franziska Steinmetz · 2017 to 2026
$4.0M
Traning Clinical Scientists in Radiological ImagingT32EB005970 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric Y Chang, Rebecca Ann Rakow-Penner · 2007 to 2026
$3.2M
Overcoming the immune-suppressive tumor microenvironment through in situ vaccination nanotechnology.U01CA218292 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIERING, STEVEN, STEINMETZ, NICOLE FRANZISKA · 2017 to 2021
$3.0M
A theranostic approach for risk stratification and intervention of deep vein thrombosis.R01HL137674 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEINMETZ, NICOLE FRANZISKA · 2017 to 2020
$2.3M
Diagnosis and longitudinal monitoring of metastatic prostate cancer through molecular MR imaging.R01CA202814 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEINMETZ, NICOLE FRANZISKA · 2016 to 2020
$2.0M
NCI NIH HHS R01 CA202814NCI NIH HHS R01 CA224605NCI NIH HHS U01 CA218292NHLBI NIH HHS R01 HL137674NIBIB NIH HHS T32 EB005970
6 · The paper itself

Abstract

Viral nanotechnology exploits the prefabricated nanostructures of viruses, which are already abundant in nature. With well-defined molecular architectures, viral nanocarriers offer unprecedented opportunities for precise structural and functional manipulation using genetic engineering and/or bio-orthogonal chemistries. In this manner, they can be loaded with diverse molecular payloads for targeted delivery. Mammalian viruses are already established in the clinic for gene therapy and immunotherapy, and inactivated viruses or virus-like particles have long been used as vaccines. More recently, plant viruses and bacteriophages have been developed as nanocarriers for diagnostic imaging, vaccine and drug delivery, and combined diagnosis/therapy (theranostics). The first wave of these novel virus-based tools has completed clinical development and is poised to make an impact on clinical practice.

Indexed as

Indicators and ReagentsBacteriophagesDrug Delivery SystemsGenetic TherapyHumansImmunotherapyNanoparticlesNanotechnologyPlant VirusesIndicators and Reagentsbacteriophagesdrug deliveryimagingimmunotherapynanomedicineplant virusesvaccinesviral nanotechnologyvirus-like particles

Identifiers

PMID32991265
PMCPMC8018517
OpenAlexW3090475430

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.