Evidence map›Paper›PMID 32991210›Full record

ArticleAmerican journal of physiology. Cell physiology2020

From initial segment to cauda: a regional characterization of mouse epididymal CD11c

A C Mendelsohn, L M Sanmarco, R G Spallanzani, D Brown, F J Quintana, S Breton, M A Battistone

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Regulatory T cells play a crucial role in maintaining sperm tolerance and male fertility.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Article
  13. The Role of Mononuclear Phagocytes in the Testes and Epididymis.International journal of molecular sciences · 2022
    Review
  14. Article
  15. Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

A C MendelsohnProgram in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
L M SanmarcoAnn Romney Center for Neurological Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
R G SpallanzaniDepartment of Immunology, Harvard Medical School, Boston, Massachusetts.
D BrownProgram in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
F J QuintanaAnn Romney Center for Neurological Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
S BretonProgram in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
M A BattistoneProgram in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-0490-9548
Harvard University · USBrigham and Women's Hospital · USBroad Institute · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Transfer of grant 5R01HD040793 - Intercellular networks and luminal acidification in the male reproductive tractR01HD040793 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI BRETON, SYLVIE · 2001 to 2021
$6.6M
Role of epididymal macrophages and dendritic cells in male reproductive functionR01HD069623 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI BRETON, SYLVIE · 2011 to 2020
$3.6M
Defining protein:protein interactions for the regulation of renal V-ATPase function: role in expression, assembly and trafficking.R01DK121848 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2019 to 2023
$2.7M
HHS | NIH | National Institute of Child Health and Human Development (NICHD) HD040793HHS | NIH | National Institute of Child Health and Human Development (NICHD) HD069623HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK121848NICHD NIH HHS R01 HD040793NICHD NIH HHS R01 HD069623NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK121848
6 · The paper itself

Abstract

Successful sperm maturation and storage rely on a unique immunological balance that protects the male reproductive organs from invading pathogens and spermatozoa from a destructive autoimmune response. We previously characterized one subset of mononuclear phagocytes (MPs) in the murine epididymis, CX3CR1

Indexed as

AnimalsBiomarkersCD11c AntigenCD4-Positive T-LymphocytesDendritic CellsEpididymisFertilityMacrophagesMaleMiceMice, TransgenicPhagocytesPhenotypeSpermatozoaBiomarkersCD11c Antigendendritic cellimmune cellsmacrophagemale reproductive tract

Identifiers

PMID32991210
PMCPMC7792679
OpenAlexW3090523525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.