ReviewCurrent pain and headache reports2020
Brain Metabolism and Structure in Chronic Migraine.
Review in Current pain and headache reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Impaired glymphatic function and advanced brain age gap in chronic migraine: a multimodal MRI study.The journal of headache and pain · 2026Article
- The Hypometabolic State of the Migraine Brain: Is a Ketogenic Diet the Answer?Brain and behavior · 2025Review
- Genetic influence of the brain imaging phenotypes, brain and cerebrospinal fluid metabolites and brain genes on migraine subtypes: a Mendelian randomization and multi-omics study.The journal of headache and pain · 2025Article
- Sub-MicroliterJournal of neurochemistry · 2025Article
- Brain connectome-based imaging markers for identifiable signature of migraine with and without aura.Quantitative imaging in medicine and surgery · 2024Article
- Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation.Scientific reports · 2023Article
- Cerebral blood flow alterations in migraine patients with and without aura: An arterial spin labeling study.The journal of headache and pain · 2022Article
- Applications of Ketogenic Diets in Patients with Headache: Clinical Recommendations.Nutrients · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThe purpose of this paper is to review and synthesize current literature in which neurochemical and structural brain imaging were used to investigate chronic migraine (CM) pathophysiology and to further discuss the clinical implications. RECENT
findingsSpectroscopic and structural MRI studies have shown the presence of both impaired metabolism and structural alterations in the brain of CM patients. Metabolic changes in key brain regions support the notion of altered energetics and homeostasis as part of CM pathophysiology. Furthermore, CM, like other chronic pain disorders, may undergo structural reorganization in pain-related brain regions following near persistent endogenous painful input. Finally, both imaging techniques may provide potential biomarkers of disease state and progression and may help guide novel therapeutic interventions or strategies. Spectroscopic and structural MRI have revealed novel aspects of CM pathophysiology. Findings from the former support the metabolic theory of migraine pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.