ArticleClinical neuroradiology2021
Introduction of CTA-index as Simplified Measuring Method for Thrombus Perviousness.
Article in Clinical neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Subtype identification of clinical and thrombus imaging features in acute ischemic stroke: using clustering analysis and principal component analysis.Scientific reports · 2025Article
- Thrombus perviousness in acute ischemic stroke: a scoping review of methodology, predictive value, and future perspectives.Neuroradiology · 2025Article
- Can micro-guidewire advancement forces predict clot consistency and location to assist the first-line technique for mechanical thrombectomy?Journal of neurointerventional surgery · 2025Article
- Current Role of CT Pulmonary Angiography in Pulmonary Embolism: A State-of-the-Art Review.Journal of imaging · 2024Review
- Dynamic Perviousness Has Predictive Value for Clot Fibrin Content in Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Dynamic Perviousness Predicts Revascularization Success in Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Computed Tomography Embolus Texture Analysis as a Prognostic Marker of Acute Pulmonary Embolism.Angiology · 2023Article
- Correlation between Thrombus Perviousness and Distal Embolization during Mechanical Thrombectomy in Acute Stroke.Diagnostics (Basel, Switzerland) · 2023Article
- CT Marker in Emergency Imaging of Acute Basilar Artery Occlusion: Thrombosis vs. Embolism.Diagnostics (Basel, Switzerland) · 2022Article
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10 authors.
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Abstract
purposeThrombus features on admission CT are useful imaging markers for clot characterization, stroke pathogenesis and outcome prediction. In this context, thrombus perviousness is a promising parameter, but reliable assessment in daily clinical practice is demanding. The aim of the present study was to evaluate an easy to assess measuring method for thrombus permeability at the time of admission.
methodsThe CTA-index, which measures relative thrombus attenuation on admission CTA, was compared to the known perviousness parameter in a cohort of 101 patients with large-vessel occlusions of the middle cerebral artery and correlated to clinical outcome parameters (mRS after 90 days, ≤2 rated as favorable). For validation, this correlation was tested in a second independent cohort (n = 87), and possible associations between the CTA-index and outcome measurements (NIHSS/mRS/mTICI) were assessed.
resultsIn the first cohort a coherence between conventional perviousness measurements and the CTA-index was shown. The CTA-index differed significantly between favorable (-0.55 ± 0.16) and non-favorable outcomes (-0.64 ± 0.14, p = 0.01). In the validation cohort this result could be independently reproduced (-0.52 ± 0.13/-0.70 ± 0.09, p < 0.01). The CTA-index showed an association with low NIHSS at discharge (p < 0.01), favorable outcome after 90 days (p < 0.001) and with better reperfusion (measured by mTICI score, p = 0.04).
conclusionThe CTA-index is an easy to assess imaging parameter on admission CTA in the acute stroke phase and is associated with angiographic and clinical outcome. It can be considered as a simplified measuring method for thrombus perviousness, which is known to provide useful information for further stroke progress and clinical course as well as therapeutic and rehabilitative decisions.
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