Evidence map›Paper›PMID 32990595›Full record

ArticleeLife2020

Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules defined by distinct pinceau sizes.

Joy Zhou, Amanda M Brown, Elizabeth P Lackey, Marife Arancillo, Tao Lin, Roy V Sillitoe

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025
    Article
  8. Deletion of the Voltage-Gated Calcium Channel Gene, CaCerebellum (London, England) · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Joy Zhou *Department of Pathology and Immunology, Baylor College of Medicine, Houston, United States.ORCID 0000-0003-1731-8800
Amanda M Brown *Department of Pathology and Immunology, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-1484-8972
Elizabeth P LackeyDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.
Marife ArancilloDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.
Tao LinDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.
Roy V SillitoeDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-6177-6190
Baylor College of Medicine · US

Funding

NRI Build-out: Advancing Translational Brain ResearchC06RR029965 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2010 to 2010
$14.9M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
CEREBELLAR FUNCTION IN TREMORR01NS100874 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2017 to 2021
$1.9M
SYNAPTIC ORIGINS OF CEREBELLAR DISEASER01NS089664 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2014 to 2018
$1.7M
The role of cerebellar activity in tremor propagationF31NS101891 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI BROWN, AMANDA MICHELLE · 2017 to 2019
$134k
NCRR NIH HHS C06 RR029965NCRR NIH HHS C06RR029965NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIH HHS F31NS101891NINDS NIH HHS F31 NS101891NINDS NIH HHS R01 NS089664NINDS NIH HHS R01NS089664NINDS NIH HHS R01 NS100874NINDS NIH HHS R01NS100874
6 · The paper itself

Abstract

Ramón y Cajal proclaimed the neuron doctrine based on circuit features he exemplified using cerebellar basket cell projections. Basket cells form dense inhibitory plexuses that wrap Purkinje cell somata and terminate as pinceaux at the initial segment of axons. Here, we demonstrate that HCN1, Kv1.1, PSD95 and GAD67 unexpectedly mark patterns of basket cell pinceaux that map onto Purkinje cell functional zones. Using cell-specific genetic tracing with an

Indexed as

AnimalsFemaleMaleMicePurkinje CellsSynaptic Transmissioncerebellumcircuitryinhibitioninterneuronmouseneurosciencepatterningpinceaux

Identifiers

PMID32990595
PMCPMC7561353
OpenAlexW3090564811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.