Evidence map›Paper›PMID 32990514›Full record

ArticleRadiology2020

Observer Performance for Detection of Pulmonary Nodules at Chest CT over a Large Range of Radiation Dose Levels.

Joel G Fletcher, David L Levin, Anne-Marie G Sykes, Rebecca M Lindell, Darin B White, Ronald S Kuzo, Vighnesh Suresh, Lifeng Yu, Shuai Leng, David R Holmes and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
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  10. Article
  11. Article
  12. Article
  13. Deep-learning lesion and noise insertion for virtual clinical trial in Chest CT.Proceedings of SPIE--the International Society for Optical Engineering · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Joel G FletcherFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-8941-5434
David L LevinFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0001-5915-6745
Anne-Marie G SykesFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-8371-0205
Rebecca M LindellFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-0510-9879
Darin B WhiteFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-8756-5412
Ronald S KuzoFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-0961-7766
Vighnesh SureshFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-0761-8204
Lifeng YuFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-4267-1326
Shuai LengFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-6453-9481
David R HolmesFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).
Akitoshi InoueFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).
Matthew P JohnsonFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-6341-7220
Rickey E CarterFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-0818-273X
Cynthia H McColloughFrom the Department of Radiology (J.G.F., D.L.L., A.M.G.S., R.M.L., D.B.W., R.S.K., V.S., L.Y., S.L., A.I., C.H.M.), Department of Physiology and Biomedical Engineering (D.R.H.), and Department of Health Science Research (M.P.J.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Science Research, Mayo Clinic, Jacksonville, Fla (R.E.C.).ORCID 0000-0002-5346-332X

Funding

Trade-offs in human observer performance, image quality metrics, and patient doseR01EB017095 · NIBIB · MAYO CLINIC ROCHESTER · PI Hao Gong, Cynthia H McCollough · 2012 to 2026
$7.0M
Critical resources to evaluate CT scan techniques and dose reduction approachesU01EB017185 · NIBIB · MAYO CLINIC ROCHESTER · PI MCCOLLOUGH, CYNTHIA H · 2013 to 2016
$3.6M
NIBIB NIH HHS R01 EB017095
6 · The paper itself

Abstract

Background There is a wide variation in radiation dose levels that can be used with chest CT in order to detect indeterminate pulmonary nodules. Purpose To compare the performance of lower-radiation-dose chest CT with that of routine dose in the detection of indeterminate pulmonary nodules 5 mm or greater. Materials and Methods In this retrospective study, CT projection data from 83 routine-dose chest CT examinations performed in 83 patients (120 kV, 70 quality reference mAs [QRM]) were collected between November 2013 and April 2014. Reference indeterminate pulmonary nodules were identified by two nonreader thoracic radiologists. By using validated noise insertion, five lower-dose data sets were reconstructed with filtered back projection (FBP) or iterative reconstruction (IR; 30 QRM with FBP, 10 QRM with IR, 5 QRM with FBP, 5 QRM with IR, and 2.5 QRM with IR). Three thoracic radiologists circled pulmonary nodules, rating confidence that the nodule was a 5-mm-or-greater indeterminate pulmonary nodule, and graded image quality. Analysis was performed on a per-nodule basis by using jackknife alternative free-response receiver operating characteristic figure of merit (FOM) and noninferiority limit of -0.10. Results There were 66 indeterminate pulmonary nodules (mean size, 8.6 mm ± 3.4 [standard deviation]; 21 part-solid nodules) in 42 patients (mean age, 51 years ± 17; 21 men and 21 women). Compared with the FOM for routine-dose CT (size-specific dose estimate, 6.5 mGy ± 1.8; FOM, 0.86 [95% confidence interval: 0.80, 0.91]), FOM was noninferior for all lower-dose configurations except for 2.5 QRM with IR. The sensitivity for subsolid nodules at 70 QRM was 60% (range, 48%-72%) and was significantly worse at a dose of 5 QRM and lower, whether or not IR was used (

Indexed as

Radiation DosageCase-Control StudiesFemaleHumansLung NeoplasmsMaleMiddle AgedMultiple Pulmonary NodulesObserver VariationRadiographic Image Interpretation, Computer-AssistedRadiography, ThoracicRetrospective StudiesSolitary Pulmonary NoduleTomography, X-Ray Computed

Identifiers

PMID32990514
PMCPMC7706885

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.