ArticleMolecular and cellular biology1987
c-mos proto-oncogene RNA transcripts in mouse tissues: structural features, developmental regulation, and localization in specific cell types.
Article in Molecular and cellular biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 155 citations in OpenAlex.
- Identification and Characterization ofBiomolecules · 2023Article
- Vertebrate Reproduction.Cold Spring Harbor perspectives in biology · 2015Review
- Article
- Mos in the oocyte: how to use MAPK independently of growth factors and transcription to control meiotic divisions.Journal of signal transduction · 2011Article
- Article
- How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor.Cell division · 2007Article
- Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos.BMC biochemistry · 2002Article
- Comparative and functional analysis of the AP2 promoter indicates that conserved octamer and initiator elements are critical for activity.Nucleic acids research · 1996Article
- Identification of a candidate c-mos repressor that restricts transcription of germ cell-specific genes.Molecular and cellular biology · 1995Article
- The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.The EMBO journal · 1993Article
- Identification of a cis acting element responsible for muscle specific expression of the c-mos protooncogene.Nucleic acids research · 1993Article
- Antisense c-myc effects on preimplantation mouse embryo development.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Identification of a negative regulatory element that inhibits c-mos transcription in somatic cells.Molecular and cellular biology · 1992Article
- An analysis of vertebrate mRNA sequences: intimations of translational control.The Journal of cell biology · 1991Review
- c-mos expression in mouse oocytes is controlled by initiator-related sequences immediately downstream of the transcription initiation site.Molecular and cellular biology · 1991Article
- Complex pattern of alternative splicing generates unusual diversity in the leader sequence of the chicken link protein mRNA.Nucleic acids research · 1991Article
- Testis-specific expression of the human MYCL2 gene.Nucleic acids research · 1991Article
- List of cloned mouse genes with unique expression patterns during spermatogenesis.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Neuropathological changes in transgenic mice carrying copies of a transcriptionally activated Mos protooncogene.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- The testis-specific transcript (ferT) of the tyrosine kinase FER is expressed during spermatogenesis in a stage-specific manner.Molecular and cellular biology · 1990Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
c-mos RNA transcripts have been previously detected in mouse gonadal tissue and in late-term embryos. Here, we show that they are also present at low levels in placenta and in adult mouse brain, kidney, mammary gland, and epididymis. Marked differences are observed in the size of the mos RNA transcripts detected in different tissues. All transcripts appear to end at the same 3' position, and the tissue-specific size variations appear to be due to the use of different promoters. For example, the testicular and ovarian RNA transcripts initiate approximately 280 and approximately 70 base pairs, respectively, upstream from the first initiation codon, but both end at a common site downstream from the mos open reading frame. The expression of mos is developmentally regulated in gonadal tissue. Thus, the level of mos transcripts in testes is low for the first 3 weeks after birth, increases at least 10-fold around day 25, and reaches adult levels by day 30. In contrast, ovaries from preweaning mice contain a higher level of mos mRNA compared to ovaries from adult mice. In cell fractionation experiments we show that mos transcripts are present in haploid germ cells. We find that these transcripts are associated with monosomes and polysomes. The peculiar pattern of mos expression in mouse gonadal tissue suggests a role for the c-mos proto-oncogene in germ cell differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.