Evidence map›Paper›PMID 32990503›Full record

Observational studyUnited European gastroenterology journal2020

Faecal microbiota transplantation for

Elisabeth M Terveer, Karuna Ew Vendrik, Rogier E Ooijevaar, Emilie van Lingen, Eline Boeije-Koppenol, Els van Nood, Abraham Goorhuis, Martijn P Bauer, Yvette H van Beurden, Marcel Gw Dijkgraaf and 7 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in United European gastroenterology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
0.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Observational
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  6. Article
  7. Review
  8. Microbiome Therapeutics for Clostridioides difficile Infection.Infectious disease clinics of North America · 2025
    Review
  9. Article
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  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Fungal and bacterial gut microbiota differ betweenMicrobiome research reports · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Rejuvenating the human gut microbiome.Trends in molecular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Elisabeth M TerveerDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Karuna Ew VendrikDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Rogier E OoijevaarDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Emilie van LingenDepartment of Gastroenterology, Leiden University Medical Center, Leiden, the Netherlands.
Eline Boeije-KoppenolDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Els van NoodDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Abraham GoorhuisDepartment of Internal Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Martijn P BauerDepartment of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Yvette H van BeurdenDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Marcel Gw DijkgraafDepartment of Epidemiology and Data Science, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Chris Jj MulderDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Christina Mje Vandenbroucke-GraulsDepartment of Medical Microbiology and Infection Control, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Jos Fml SeegersUnaffiliated.
Joffrey van PrehnDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Hein W VerspagetDepartment of Gastroenterology, Leiden University Medical Center, Leiden, the Netherlands.
Ed J KuijperDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Josbert J KellerDepartment of Gastroenterology, Leiden University Medical Center, Leiden, the Netherlands.
Leiden University Medical Center · NLAmsterdam University Medical Centers · NLErasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Netherlands Donor Feces Bank provides standardized ready-to-use donor faecal suspensions for faecal microbiota transplantation treatment of patients with recurrent

objectiveThe purpose of this study was evaluation of safety, feasibility and outcome of faecal microbiota transplantation facilitated by a national stool bank.

methodsThe methods used included: observational cohort study of donors and recipients of faecal suspensions; assessment of donor screening and patient selection performed by an expert panel of medical microbiologists, gastroenterologists and infectious disease specialists; and patient outcome evaluated at different timepoints after faecal microbiota transplantation.

resultsOf 871 volunteers who registered as a potential faeces donor, 16 (2%) became active donors. Nine donors stopped or were excluded after a mean donation period of 5.7 months. In 2016-2019, 47 (27%) of 176 requests for faecal microbiota transplantations were deemed not indicated by the expert panel. In total, 129 patients with recurrent

conclusionFaecal suspensions provided by a centralized stool bank, supported by a multidisciplinary expert team, resulted in effective, appropriate and safe application of faecal microbiota transplantation for recurrent LEVEL OF EVIDENCE: Level II, prospective cohort study.

Indexed as

Biological Specimen BanksAbdominal PainAdultAnti-Bacterial AgentsClostridioides difficileClostridium InfectionsDiarrheaDonor SelectionFeasibility StudiesFecal Microbiota TransplantationFemaleFollow-Up StudiesHumansLiving DonorsMaleMiddle AgedAnti-Bacterial AgentsClostridioides difficilecure ratedonorFaecal microbiota transplantationmicrobiomemicrobiota modifying therapystool bank

Identifiers

PMID32990503
PMCPMC7724536
OpenAlexW3090456409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.