Evidence map›Paper›PMID 32990406›Full record

ArticleBrain and behavior2020

Pathways to post-traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults.

Stacey Subbie-Saenz de Viteri, Ashwini Pandey, Gayathri Pandey, Chella Kamarajan, Rebecca Smith, Andrey Anokhin, Lance Bauer, Annah Bender, Grace Chan, Danielle Dick and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Does Reflective Thinking Improve the Ability to Plan in Light and Heavy Drinkers? A Clinical-Experimental Model of Metacognition.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  2. Childhood Trauma andmedRxiv : the preprint server for health sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Stacey Subbie-Saenz de ViteriState University of New York Downstate Health Sciences University, Brooklyn, New York, USA.ORCID 0000-0002-0569-9207
Ashwini PandeyState University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Gayathri PandeyState University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Chella KamarajanState University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Rebecca SmithVirginia Commonwealth University, Richmond, Virginia, USA.
Andrey AnokhinWashington University School of Medicine, St. Louis, Missouri, USA.
Lance BauerUniversity of Connecticut School of Medicine, Farmington, Connecticut, USA.
Annah BenderUniversity of Missouri, St. Louis, Missouri, USA.
Grace ChanUniversity of Connecticut School of Medicine, Farmington, Connecticut, USA.
Danielle DickVirginia Commonwealth University, Richmond, Virginia, USA.
Howard EdenbergIndiana University School of Medicine, Indianapolis, Indiana, USA.
Sivan KinreichState University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
John KramerUniversity of Iowa, Iowa City, Iowa, USA.
Marc SchuckitUniversity of California San Diego, California, USA.
Yong ZangIndiana University School of Medicine, Indianapolis, Indiana, USA.
Vivia McCutcheonWashington University School of Medicine, St. Louis, Missouri, USA.
Kathleen BucholzWashington University School of Medicine, St. Louis, Missouri, USA.
Bernice PorjeszState University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Jacquelyn L MeyersState University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
State University of New York · USWashington University in St. Louis · USIndiana University School of MedicineUniversity of Connecticut · USVirginia Commonwealth University · USUniversity of California San Diego · USUniversity of Iowa · USUniversity of Missouri–St. Louis · US

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI Yunlong Liu · 1989 to 2026
$162.7M
Neurocognitive and genetic influences on post-traumatic stress and risky alcohol use in trauma-exposed adolescents and young adult offspring from families enriched with Alcohol Use DisordersF31AA026499 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI SAENZ DE VITERI, STACEY · 2018 to 2019
$72k
NIAAA NIH HHS F31 AA026499NIAAA NIH HHS U10 AA008401
6 · The paper itself

Abstract

introductionFamily history (FH) of alcohol dependence is likely to increase the risk of trauma exposure, post-traumatic stress disorder (PTSD), and alcohol dependence. FH of alcohol dependence and trauma has been separately shown to adversely affect planning/problem-solving aspects of executive function. However, few studies have examined these risk factors in an integrated model.

methodsUsing data from trauma-exposed individuals from the Collaborative Study on the Genetics of Alcoholism prospective cohort (N = 1,860), comprising offspring from alcohol-dependent high-risk and comparison families (mean age [SE] = 21.9 [4.2]), we investigated associations of trauma (nonsexual assaultive, nonassaultive, sexual assaultive) with DSM-IV PTSD and alcohol dependence symptom counts, and planning/problem-solving abilities assessed using the Tower of London Test (TOLT). Moderating effects of family history density of alcohol use disorder (FHD) on these associations and sex differences were explored.

resultsFamily history density was positively associated with PTSD in female participants who endorsed a sexual assaultive trauma. Exposure to nonsexual assaultive trauma was associated with more excess moves made on the TOLT.

conclusionFindings from this study demonstrate associations with PTSD and alcohol dependence symptom counts, as well as poor problem-solving ability in trauma-exposed individuals from families densely affected with alcohol dependence, depending on trauma type, FHD, and sex. This suggests that having a FH of alcohol dependence and exposure to trauma during adolescence may be associated with more PTSD and alcohol dependence symptoms, and poor problem-solving abilities in adulthood.

Indexed as

AlcoholismStress Disorders, Post-TraumaticAdolescentAdultCohort StudiesExecutive FunctionFemaleHumansMaleProspective StudiesYoung Adultalcoholismexecutive functionpost-traumatic stress disordertrauma

Identifiers

PMID32990406
PMCPMC7667345
OpenAlexW3090028175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.