Evidence map›Paper›PMID 32990305›Full record

ArticleThe Journal of infectious diseases2021

Adoptive Transfer of Serum Samples From Children With Invasive Staphylococcal Infection and Protection Against Staphylococcus aureus Sepsis.

Chih-Ming Tsai, Nicole Soper, Monique Bennett, Jonathan K Fallon, Ashlin R Michell, Galit Alter, George Y Liu, Isaac Thomsen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Divergent humoral immune signatures in response to Klebsiella pneumoniae bacteremia.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
    Article
  2. Article
  3. LinkingAntibiotics (Basel, Switzerland) · 2024
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chih-Ming TsaiDepartment of Pediatrics, Division of Infectious Diseases, University of California, San Diego, California, USA.
Nicole SoperDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Monique BennettDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jonathan K FallonRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
Ashlin R MichellRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
Galit AlterRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
George Y LiuDepartment of Pediatrics, Division of Infectious Diseases, University of California, San Diego, California, USA.
Isaac ThomsenDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ragon Institute of MGH, MIT and Harvard · USVanderbilt University Medical Center · USUniversity of California San Diego · US

Funding

Functional Antibody Repertoire Against S. aureus Leukocidins after Invasive Human InfectionR01AI139172 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E · 2019 to 2023
$3.5M
Generating protective immunity to Staphylococcus aureusR01AI127406 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI LIU, GEORGE Y, MARTINS, GISLAINE A · 2017 to 2021
$2.8M
Evaluating the Functional Antibody Response to Pediatric S. aureus InfectionsK23AI113150 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI THOMSEN, ISAAC P · 2014 to 2018
$887k
NIAID NIH HHS K23 AI113150NIAID NIH HHS R01 AI127406NIAID NIH HHS R01 AI139172
6 · The paper itself

Abstract

A successful Staphylococcus aureus vaccine remains elusive, and one controversy in the field is whether humans generate a protective adaptive immune response to infection. We developed a bacterial challenge murine assay that directly assesses the protective capacity of adoptively transferred human serum samples. We first validated the model by showing that postpneumococcal vaccine serum samples from humans induced effective clearance of Streptococcus pneumoniae in mice. We then found that human serum samples adoptively transferred from children with invasive S. aureus infections exhibited protection from disease in a murine model, with some samples conferring near complete protection. These findings demonstrate that human serum samples are capable of conferring a protective adaptive response generated by humans during invasive staphylococcal disease, allowing for the study of protective factors in a murine model. Identification of the protective factors present in the most efficacious serum samples would be of high interest as potential staphylococcal vaccine candidates or passive therapeutics.

Indexed as

Adoptive TransferSepsisStaphylococcal InfectionsAnimalsAntibodies, BacterialChildDisease Models, AnimalHumansMiceStaphylococcus aureusAntibodies, Bacterialadaptive host responseantibodiespediatric infectionStaphylococcus aureus

Identifiers

PMID32990305
PMCPMC8030728
OpenAlexW3090493079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.