Evidence map›Paper›PMID 32990120›Full record

ArticleJournal of the American Heart Association2020

Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury.

Huijing Xia, Zhen Li, Thomas E Sharp, David J Polhemus, Jean Carnal, Karl H Moles, Ya-Xiong Tao, John Elrod, Josef Pfeilschifter, Karl-Friedrich Beck and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Total Flavones ofCurrent issues in molecular biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Using mechanism-based combinations of HNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Mitochondrial HCirculation research · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Huijing XiaCardiovascular Center of Excellence Louisiana State University Health Sciences Center New Orleans LA.
Zhen LiCardiovascular Center of Excellence Louisiana State University Health Sciences Center New Orleans LA.
Thomas E SharpCardiovascular Center of Excellence Louisiana State University Health Sciences Center New Orleans LA.
David J PolhemusCardiovascular Center of Excellence Louisiana State University Health Sciences Center New Orleans LA.
Jean CarnalCardiovascular Center of Excellence Louisiana State University Health Sciences Center New Orleans LA.
Karl H MolesCardiovascular Center of Excellence Louisiana State University Health Sciences Center New Orleans LA.
Ya-Xiong TaoDepartment of Anatomy, Physiology, and Pharmacology College of Veterinary Medicine Auburn University Auburn AL.
John ElrodCenter for Translational Medicine Lewis Katz School of Medicine Temple University Philadelphia PA.
Josef PfeilschifterInstitute of Pharmacology and Toxicology Goethe University Frankfurt am Main Germany.
Karl-Friedrich BeckInstitute of Pharmacology and Toxicology Goethe University Frankfurt am Main Germany.
David J LeferCardiovascular Center of Excellence Louisiana State University Health Sciences Center New Orleans LA.
Louisiana State University Health Sciences Center New Orleans · USGoethe University Frankfurt · DEAuburn University · USTemple University · US

Funding

Roles of Endothelial and Smooth Muscle KATP Channels in Myocardial Ischemic InjuryR01HL146514 · NHLBI · LSU HEALTH SCIENCES CENTER · PI COETZEE, WILLIAM A, LEFER, DAVID JOSEPH · 2020 to 2023
$3.0M
Cardioprotective Actions of Hydrogen SulfideR01HL092141 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2013
$1.9M
Endogenous Hydrogen Sulfide Enzymes in Heart FailureR01HL146098 · NHLBI · LSU HEALTH SCIENCES CENTER · PI XIA, HUIJING · 2019 to 2022
$1.6M
Cardioprotective Role of HumaninR56HL137711 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEFER, DAVID JOSEPH, MUZUMDAR, RADHIKA HIREN · 2018 to 2018
$674k
NHLBI NIH HHS R01 HL092141NHLBI NIH HHS R01 HL146098NHLBI NIH HHS R01 HL146514NHLBI NIH HHS R56 HL137711
6 · The paper itself

Abstract

Background Hydrogen sulfide (H

Indexed as

AnimalsAorta, ThoracicCystathionine gamma-LyaseEndothelial CellsExercise ToleranceHydrogen SulfideMiceMice, TransgenicMyocardial Reperfusion InjuryMyocardiumNitric OxideNitric Oxide SynthaseSignal TransductionCystathionine gamma-LyaseHydrogen SulfideNitric OxideNitric Oxide Synthasecardioprotectioncystathionine γ‐lyaseendothelial functionhydrogen sulfidenitric oxide

Identifiers

PMID32990120
PMCPMC7792404
OpenAlexW3090412465

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.