Evidence map›Paper›PMID 32989986›Full record

ArticleACS sensors2020

Colorimetric Test for Fast Detection of SARS-CoV-2 in Nasal and Throat Swabs.

Bartolomeo Della Ventura, Michele Cennamo, Antonio Minopoli, Raffaele Campanile, Sergio Bolletti Censi, Daniela Terracciano, Giuseppe Portella, Raffaele Velotta

Open access · hybridAbstract read
In one paragraph

Article in ACS sensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.

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  19. Two-Dimensional (2D) materials in the detection of SARS-CoV-2.Microchemical journal : devoted to the application of microtechniques in all branches of science · 2023
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bartolomeo Della VenturaDipartimento di Fisica Ettore Pancini, Università di Napoli Federico II, Via Cintia, 26 Ed. 6, 80126 Napoli, Italy.
Michele CennamoDipartimento di Scienze Mediche Traslazionali, Università di Napoli Federico II, Via Pansini, 5, 80131 Napoli, Italy.
Antonio MinopoliDipartimento di Fisica Ettore Pancini, Università di Napoli Federico II, Via Cintia, 26 Ed. 6, 80126 Napoli, Italy.
Raffaele CampanileDipartimento di Fisica Ettore Pancini, Università di Napoli Federico II, Via Cintia, 26 Ed. 6, 80126 Napoli, Italy.
Sergio Bolletti CensiCosvitec scarl, Via Galileo Ferraris, 171, 80142 Napoli, Italy.
Daniela TerraccianoDipartimento di Scienze Mediche Traslazionali, Università di Napoli Federico II, Via Pansini, 5, 80131 Napoli, Italy.
Giuseppe PortellaDipartimento di Scienze Mediche Traslazionali, Università di Napoli Federico II, Via Pansini, 5, 80131 Napoli, Italy.
Raffaele VelottaDipartimento di Fisica Ettore Pancini, Università di Napoli Federico II, Via Cintia, 26 Ed. 6, 80126 Napoli, Italy.ORCID 0000-0003-1077-8353
University of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mass testing is fundamental to face the pandemic caused by the coronavirus SARS-CoV-2 discovered at the end of 2019. To this aim, it is necessary to establish reliable, fast, and cheap tools to detect viral particles in biological material so to identify the people capable of spreading the infection. We demonstrate that a colorimetric biosensor based on gold nanoparticle (AuNP) interaction induced by SARS-CoV-2 lends itself as an outstanding tool for detecting viral particles in nasal and throat swabs. The extinction spectrum of a colloidal solution of multiple viral-target gold nanoparticles-AuNPs functionalized with antibodies targeting three surface proteins of SARS-CoV-2 (spike, envelope, and membrane)-is red-shifted in few minutes when mixed with a solution containing the viral particle. The optical density of the mixed solution measured at 560 nm was compared to the threshold cycle (

Indexed as

BetacoronavirusBiosensing TechniquesColorimetryCoronavirus InfectionsCOVID-19GoldHumansMembrane ProteinsMetal NanoparticlesNasal MucosaPandemicsPharynxPhotochemistryPneumonia, ViralPolymerase Chain ReactionSARS-CoV-2GoldMembrane ProteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral Envelope Proteinsantibodycolorimetric biosensorsgold nanoparticlesphotochemical immobilization techniquepoint-of-care deviceSARS-CoV-2

Identifiers

PMID32989986
PMCPMC7534800
OpenAlexW3088627492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.