Evidence map›Paper›PMID 32989916›Full record

ArticleBrain and behavior2020

Multimodal treatment of persistent postural-perceptual dizziness.

Hubertus Axer, Sigrid Finn, Alexander Wassermann, Orlando Guntinas-Lichius, Carsten M Klingner, Otto W Witte

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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  5. [Application of computerized cognitive behavioral therapy in patients with persistent postural-perceptual dizziness].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
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  7. Treatment of Functional Neurological Disorders.Journal of clinical neurology (Seoul, Korea) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hubertus AxerCenter for Vertigo and Dizziness, Department of Neurology, Jena University Hospital, Jena, Germany.ORCID 0000-0002-3191-2796
Sigrid FinnCenter for Vertigo and Dizziness, Department of Neurology, Jena University Hospital, Jena, Germany.
Alexander WassermannCenter for Vertigo and Dizziness, Department of Neurology, Jena University Hospital, Jena, Germany.
Orlando Guntinas-LichiusDepartment of Otorhinolaryngology, Jena University Hospital, Jena, Germany.
Carsten M KlingnerCenter for Vertigo and Dizziness, Department of Neurology, Jena University Hospital, Jena, Germany.
Otto W WitteCenter for Vertigo and Dizziness, Department of Neurology, Jena University Hospital, Jena, Germany.
Jena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPersistent postural-perceptual dizziness (PPPD) is a chronic disorder with fluctuating symptoms of dizziness, unsteadiness, or vertigo for at least three months. Its pathophysiological mechanisms give theoretical support for the use of multimodal treatment. However, there are different therapeutic programs and principles available, and their clinical effectiveness remains elusive.

methodsA database of patients who participated in a day care multimodal treatment program was analyzed regarding the therapeutic effects on PPPD. Vertigo Severity Scale (VSS) and Hospital Anxiety and Depression Scale (HADS) were assessed before and 6 months after therapy.

resultsOf a total of 657 patients treated with a tertiary care multimodal treatment program, 46.4% met the criteria for PPPD. PPPD patients were younger than patients with somatic diagnoses and complained more distress due to dizziness. 63.6% completed the follow-up questionnaire. All patients showed significant changes in VSS and HADS anxiety, but the PPPD patients generally showed a tendency to improve more than the patients with somatic diagnoses. The change in the autonomic-anxiety subscore of VSS only reached statistical significance when comparing PPPD with somatic diagnoses (p = .002).

conclusionsTherapeutic principles comprise cognitive-behavioral therapy, vestibular rehabilitation exercises, and serotonergic medication. However, large-scale, randomized, controlled trials are still missing. Follow-up observations after multimodal interdisciplinary therapy reveal an improvement in symptoms in most patients with chronic dizziness. The study was not designed to detect diagnosis-specific effects, but patients with PPPD and patients with other vestibular disorders benefit from multimodal therapies.

Indexed as

DizzinessVestibular DiseasesAnxietyCombined Modality TherapyHumansVertigocognitive-behavioral therapyfunctional dizzinessmultimodal treatmentpersistent postural-perceptual dizzinessvestibular rehabilitation

Identifiers

PMID32989916
PMCPMC7749543
OpenAlexW3089782056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.