Evidence map›Paper›PMID 32989782›Full record

ArticleGenetic epidemiology2021

Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.

Pagé C Goddard, Kevin L Keys, Angel C Y Mak, Eunice Y Lee, Amy K Liu, Lesly-Anne Samedy-Bates, Oona Risse-Adams, María G Contreras, Jennifer R Elhawary, Donglei Hu and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetic epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Asthma-Genomic Advances Toward Risk Prediction.Clinics in chest medicine · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Pagé C GoddardDepartment of Genetics, Stanford University, Stanford, California, USA.
Kevin L KeysDepartment of Medicine, University of California, San Francisco, California, USA.
Angel C Y MakDepartment of Medicine, University of California, San Francisco, California, USA.
Eunice Y LeeDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.
Amy K LiuDepartment of Neurology, University of California, San Francisco, California, USA.
Lesly-Anne Samedy-BatesDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.
Oona Risse-AdamsDepartment of Medicine, University of California, San Francisco, California, USA.
María G ContrerasDepartment of Medicine, University of California, San Francisco, California, USA.
Jennifer R ElhawaryDepartment of Medicine, University of California, San Francisco, California, USA.
Donglei HuDepartment of Medicine, University of California, San Francisco, California, USA.
Scott HuntsmanDepartment of Medicine, University of California, San Francisco, California, USA.
Sam S OhDepartment of Medicine, University of California, San Francisco, California, USA.
Sandra SalazarDepartment of Medicine, University of California, San Francisco, California, USA.
Celeste EngDepartment of Medicine, University of California, San Francisco, California, USA.
Blanca E HimesDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Marquitta J WhiteDepartment of Medicine, University of California, San Francisco, California, USA.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, California, USA.
University of California, San Francisco · USStanford University · USUniversity of California, Santa Cruz · USUniversity of Pennsylvania · US

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2M
New Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1M
UCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4M
SF BUILD: Enabling Students to Represnt in ScienceUL1GM118985 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$18.2M
UPGRADE OF COMMUNICATIONS INFRASTRUCTURET34GM008574 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI BAYLISS, FRANK T, ESQUERRA, RAYMOND M. · 1996 to 2021
$14.5M
Natural History of Viral Induced Airway Dysfunction and Asthma in Minority ChildrenU01HL138626 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RODRIGUEZ-SANTANA, JOSE, SEIBOLD, MAX A · 2018 to 2022
$10.0M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4M
SF BUILD: Enabling Students to Represent in ScienceTL4GM118986 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2022
$5.4M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
NCATS NIH HHS UL1 TR001872NHGRI NIH HHS K22 HG000044NHGRI NIH HHS T32 HG000044NHGRI NIH HHS U01 HG007419NHGRI NIH HHS U01 HG009080NHLBI NIH HHS K01 HL140218NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL133433NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL141845NHLBI NIH HHS R01 HL141992NHLBI NIH HHS U01 HL138626NICHD NIH HHS R01 HD085993NIDDK NIH HHS R01 DK113003NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS K12 GM081266NIGMS NIH HHS RL5 GM118984NIGMS NIH HHS T32 GM007546NIGMS NIH HHS T34 GM008574NIGMS NIH HHS TL4 GM118986NIGMS NIH HHS UL1 GM118985NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443NIMHD NIH HHS R56 MD013312
6 · The paper itself

Abstract

Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung function present with diseases such as asthma. Administration of BD medication can partially or fully restore lung function as measured by pulmonary function tests. The genetics of baseline lung function measures taken before BD medication have been extensively studied, and the genetics of the BD response itself have received some attention. However, few studies have focused on the genetics of post-BD lung function. To address this gap, we analyzed lung function phenotypes in 1103 subjects from the Study of African Americans, Asthma, Genes, and Environment, a pediatric asthma case-control cohort, using an integrative genomic analysis approach that combined genotype, locus-specific genetic ancestry, and functional annotation information. We integrated genome-wide association study (GWAS) results with an admixture mapping scan of three pulmonary function tests (forced expiratory volume in 1 s [FEV

Indexed as

AsthmaGenome-Wide Association StudyBlack or African AmericanChildForced Expiratory VolumeGenomicsHumansLeukocytes, MononuclearLungPolymorphism, Single NucleotideadmixtureAfrican AmericanasthmaGWASintegrative genomic analysislung function

Identifiers

PMID32989782
PMCPMC7902343
OpenAlexW3090470144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.