Evidence map›Paper›PMID 32989675›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2021

Enhanced anticancer activity and endocytic mechanisms by polymeric nanocarriers of n-butylidenephthalide in leukemia cells.

X-F Huang, P-T Chen, Y-L Lin, M-S Lee, K-F Chang, K-W Liao, G-T Sheu, M-C Hsieh, N-M Tsai

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Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

X-F HuangInstitute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC.
P-T ChenClinical Laboratory, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan, ROC.
Y-L LinAgricultural Biotechnology Research Center, Academia Sinica, Taipei, 11529, Taiwan, ROC.
M-S LeeDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC.
K-F ChangInstitute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC.
K-W LiaoDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, 30010, Taiwan, ROC.
G-T SheuInstitute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC.
M-C Hsieh *Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC.
N-M Tsai *Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, 40201, Taiwan, ROC. numan@csmu.edu.tw.ORCID http://orcid.org/0000-0002-2629-1833
Chung Shan Medical University Hospital · TWChung Shan Medical University · TWAgricultural Biotechnology Research Center, Academia Sinica · TWNational Yang Ming Chiao Tung University · TW

Funding

Chung Shan Medical University Hospital CSH-2014-A-023Chung Shan Medical University Hospital CSH-2014-C-031
6 · The paper itself

Abstract

purposeThe purpose of this study was to investigate the antitumor mechanisms of n-butylidenephthalide (BP) and to further examine the delivery efficacy of polycationic liposome containing PEI and polyethylene glycol complex (LPPC)-encapsulated BP in leukemia cells.

methodsMTS, flow cytometric and TUNEL assays were performed to assess cell viability and apoptosis. BP and BP/LPPC complex delivery efficiency was analyzed by full-wavelength fluorescent scanner and fluorescence microscope. The expressions of cell cycle- and apoptosis-related proteins were conducted by Western blotting.

resultsThe results showed that BP inhibited leukemia cell growth by inducing cell cycle arrest and cell apoptosis. LPPC-encapsulated BP rapidly induced endocytic pathway activation, resulting in the internalization of BP into leukemia cells, causing cell apoptosis within 1 h.

conclusionsLPPC encapsulation enhanced the cytotoxic activity of BP and did not influence the effects of BP induction that suggested LPPC-encapsulated BP might be developed as anti-leukemia drugs in future.

Indexed as

Drug CarriersApoptosisCell SurvivalEndocytosisHumansLeukemiaLiposomesNanotechnologyPhthalic AnhydridesPolyelectrolytesTumor Cells, CulturedbutylidenephthalideDrug CarriersLiposomesPhthalic AnhydridesPolyelectrolytesCell apoptosisCell cycleLeukemian-Butylidenephthalide (BP)Polycationic liposome containing PEI and polyethylene glycol complex (LPPC)

Identifiers

PMID32989675
OpenAlexW3091346572

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.