Evidence map›Paper›PMID 32989673›Full record

ArticleSleep & breathing = Schlaf & Atmung2021

Obstructive Sleep Apnea and Risk of COVID-19 Infection, Hospitalization and Respiratory Failure.

Matthew B Maas, Minjee Kim, Roneil G Malkani, Sabra M Abbott, Phyllis C Zee

Open access · bronzeAbstract read
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Matthew B MaasDivision of Stroke and Neurocritical Care, Department of Neurology, Northwestern University, 625 N Michigan Ave, Suite 1150, Chicago, IL, 60611, USA. mbmaas@northwestern.edu.ORCID https://orcid.org/0000-0003-1859-8357
Minjee KimDivision of Stroke and Neurocritical Care, Department of Neurology, Northwestern University, 625 N Michigan Ave, Suite 1150, Chicago, IL, 60611, USA.ORCID https://orcid.org/0000-0002-2720-1940
Roneil G MalkaniCenter for Circadian and Sleep Medicine, Northwestern University, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-6712-4003
Sabra M AbbottCenter for Circadian and Sleep Medicine, Northwestern University, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-8947-9649
Phyllis C ZeeCenter for Circadian and Sleep Medicine, Northwestern University, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-6296-6685
Northwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
SLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI TUREK, FRED W · 1994 to 2021
$31.5M
Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)UL1TR000150 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2012 to 2013
$10.1M
Strengthening circadian signals to enhance cardiometabolic functionR01HL140580 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZEE, PHYLLIS C. · 2017 to 2021
$3.4M
Circadian Dysfunction, Encephalopathy, and Cognitive Outcomes after Critical IllnessK23NS092975 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MAAS, MATTHEW BRANDON · 2015 to 2019
$886k
NCATS NIH HHS UL1 TR000150NCATS NIH HHS UL1TR000150NCATS NIH HHS UL1 TR001422NHLBI NIH HHS R01 HL140580NHLBI NIH HHS R01HL140580NIA NIH HHS P01 AG011412NIA NIH HHS P01AG011412NINDS NIH HHS K23 NS092975NINDS NIH HHS K23NS092975
6 · The paper itself

Abstract

purposeTo study the relationship between OSA and risk of COVID-19 infection and disease severity, identified by the need for hospitalization and progression to respiratory failure.

methodsWe queried the electronic medical record system for an integrated health system of 10 hospitals in the Chicago metropolitan area to identify cases of COVID-19. Comorbidities and outcomes were ascertained by ICD-10-CM coding and medical record data. We evaluated the risk for COVID-19 diagnosis, hospitalization, and respiratory failure associated with OSA by univariate tests and logistic regression, adjusting for diabetes, hypertension, and BMI to account for potential confounding in the association between OSA, COVID-19 hospitalization, and progression to respiratory failure.

resultsWe identified 9405 COVID-19 infections, among which 3185 (34%) were hospitalized and 1779 (19%) were diagnosed with respiratory failure. OSA was more prevalent among patients requiring hospitalization than those who did not (15.3% versus 3.4%, p < 0.0001; OR 5.20, 95% CI (4.43, 6.12)), and among those who progressed to respiratory failure (19.4% versus 4.5%, p < 0.0001; OR 5.16, 95% CI (4.41, 6.03)). After adjustment for diabetes, hypertension, and BMI, OSA was associated with increased risk for hospitalization (OR 1.65; 95% CI (1.36, 2.02)) and respiratory failure (OR 1.98; 95% CI (1.65, 2.37)).

conclusionsPatients with OSA experienced approximately 8-fold greater risk for COVID-19 infection compared to a similar age population receiving care in a large, racially, and socioeconomically diverse healthcare system. Among patients with COVID-19 infection, OSA was associated with increased risk of hospitalization and approximately double the risk of developing respiratory failure.

Indexed as

AdultAgedComorbidityCOVID-19COVID-19 TestingHospitalizationHumansMaleMiddle AgedRespiratory InsufficiencyRisk AssessmentRisk FactorsSleep Apnea, ObstructiveCoronavirusCOVID-19Obstructive sleep apneaOutcomes

Identifiers

PMID32989673
PMCPMC7521948
OpenAlexW3090514326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.