ArticleMolecular and cellular biochemistry2021
Memory impairment of chewing-side preference mice is associated with 5-HT-BDNF signal pathway.
Article in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment.Frontiers in neuroscience · 2022Pooled it
- [Clinical symptoms and cone beam computed tomography imaging analysis of patients with temporomandibular joint osteoarthritis with chewing side preference before and after treatment of stabilization splint].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Article
- Chewing modulates theta oscillation and functional connectivity of the frontocentral cortex in attention and working memory.Scientific reports · 2025Article
- Leptin From Fibro-Adipogenic Progenitor Cells (FAPs) Regulates Masseter Muscle Disuse Atrophy and Ectopic Fat Accumulation.Journal of cachexia, sarcopenia and muscle · 2025Article
- Musculoskeletal Deficits and Cognitive Impairment: Epidemiological Evidence and Biological Mechanisms.Current osteoporosis reports · 2022Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Although tooth loss is a known risk factor of cognitive function, whether and how the chewing-side preference (CSP) affects memory impairment still remains unclear. This study evaluates the behavior changes in mice after the loss of teeth on one side and explores the role of serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) signal pathway within these changes. To this end, CSP mouse models with either the removal of left unilateral molars (CSP-L) or right unilateral molars (CSP-R) were established. Morris water maze test and passive avoidance test were performed to evaluate the mice's learning and memory capacity in the 4th and 8th weeks. The correlation between CSP and brain function changes was validated with changes in 5-HT and BDNF levels. CSP mice's cognitive function was found to be decreased, along with a significant decline in 5-HT1A level, especially in CSP-R mice. BDNF and TrkB levels in CSP-R mice were also significantly lowered. These findings suggest that CSP results in memory impairment, which is associated with the 5-HT-BDNF signaling pathway.
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Registered trials
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