ArticleJournal of cancer research and clinical oncology2021
Mendelian randomization study indicates lack of causal relationship between physical activity and lung cancer.
Article in Journal of cancer research and clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Association between strenuous sports or other exercises and lung cancer risk: a mendelian randomization study.Translational lung cancer research · 2024Article
- Exploring the link between walking and lung cancer risk: a two-stage Mendelian randomization analysis.BMC pulmonary medicine · 2024Article
- Physical Activity, Sedentary Behavior, and Pancreatic Cancer Risk: A Mendelian Randomization Study.Journal of the Endocrine Society · 2024Article
- Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Mendelian randomization to explore the direct or mediating associations between socioeconomic status and lung cancer.Frontiers in oncology · 2023Article
- Association between physical activity and cancer risk among Chinese adults: a 10-year prospective study.The international journal of behavioral nutrition and physical activity · 2022Article
- A bidirectional Mendelian randomization study supports the causal effects of a high basal metabolic rate on colorectal cancer risk.PloS one · 2022Article
- Univariable and Multivariable Two-Sample Mendelian Randomization Investigating the Effects of Leisure Sedentary Behaviors on the Risk of Lung Cancer.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious researches have indicated physical activity (PA) may be associated with lower risk of lung cancer. However, causal relationship between PA and risk of lung cancer is not clear. We aimed to inspect the causal effect of PA on lung cancer.
methodsWe analyzed summary data of accelerator-measured PA and lung cancer from the genome-wide association study (GWAS) using two-sample Mendelian randomization (MR) method. We obtained summary data of accelerator-measured PA from UK Biobank, data of lung cancer patients from Consortium and International Lung Cancer Consortium (ILCCO) to investigate possible causal effect of PA on lung cancer.
resultsAccording to result of MR using inverse variance weighted method (IVW), we found that genetically predicted higher PA level did not causally decrease risk of lung cancer (OR 0.95, 95% CI 0.88-1.03, p = 0.238). Results of MR-Egger and weighted median method were consistent with IVW method.
conclusionOur mendelian randomization study showed that genetically higher PA is not causally associated with risk of lung cancer. More researches are needed to investigate relationship between PA and lung cancer.
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