Evidence map›Paper›PMID 32989586›Full record

ArticleCellular and molecular neurobiology2022

Apelin Receptor Signaling Protects GT1-7 GnRH Neurons Against Oxidative Stress In Vitro.

Hatice Burcu Şişli, Taha Bartu Hayal, Selinay Şenkal, Binnur Kıratlı, Derya Sağraç, Selin Seçkin, Murat Özpolat, Fikrettin Şahin, Bayram Yılmaz, Ayşegül Doğan

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Yin and Yang Effect of the Apelinergic System in Oxidative Stress.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Article
  8. Article
  9. CREB1ACS omega · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hatice Burcu Şişli *Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Taha Bartu Hayal *Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Selinay ŞenkalDepartment of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Binnur KıratlıDepartment of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Derya SağraçDepartment of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Selin SeçkinDepartment of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Murat ÖzpolatDepartment of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Fikrettin ŞahinDepartment of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Bayram YılmazDepartment of Physiology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Ayşegül DoğanDepartment of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey. aysegul.dogan@yeditepe.edu.tr.ORCID http://orcid.org/0000-0003-4160-2270
Yeditepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothalamic-pituitary-adrenal (HPA) axis regulates stress response in the body and abnormal increase in oxidative stress contributes to the various disease pathogenesis. Although hypothalamic distribution of Apelin receptor (APLNR) has been studied, the potential regulatory role in hormone releasing function of hypothalamus in response to stress is not well elucidated yet. To determine whether APLNR is involved in the protection of the hypothalamus against oxidative stress, gonadotropin-releasing hormone (GnRH) cells were used as an in vitro model system. GT1-7 mouse hypothalamic neuronal cell line was subjected to H

Indexed as

Apelin ReceptorsGonadotropin-Releasing HormoneNeuronsOxidative StressAnimalsHydrogen PeroxideHypothalamusMiceApelin ReceptorsAplnr protein, mouseGonadotropin-Releasing HormoneHydrogen PeroxideApelinApelin receptorGonadotropin-releasing hormoneHypothalamusOxidative stress

Identifiers

PMID32989586
PMCPMC11441187
OpenAlexW3089675407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.